Measuring lung function in infants with bronchopulmonary dysplasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to utilize the forced oscillometry technique (FOT) to assess pulmonary mechanics and function in both term and premature infants diagnosed with bronchopulmonary dysplasia (BPD). The FOT is a non-invasive method that measures respiratory mechanics without requiring infants to perform specific breathing maneuvers, making it suitable for this vulnerable population. The study will employ a new device called tremoflo N-100, designed specifically for infants, to measure lung function quickly while they are sleeping. This approach seeks to provide clinically meaningful data that can enhance the understanding and management of respiratory conditions in infants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Preterm Cohort:

* Premature infants with BPD who are in room air based on the (per NICHD definition)
* Premature infants with BPD who are receiving low flow O2 support and able to maintain normal spO2 in Room air for brief period ( up to 3 minutes) Term Cohort without pulmonary disease
* Infants \>36 weeks gestational age without pulmonary disease
* Infants \< 4 weeks of age

Outpatient Cohort:

* Former preterm infants \< 32 weeks at birth
* Those with BPD based on NIH 2001 definition
* Seen prior to 2 years of age

Exclusion Criteria:

* Infants with BPD requiring invasive or non-invasive positive pressure ventilation
* Infants with BPD who have associated genetic diagnosis or major congenital anomalies.

Where it's running

• Children's Mercy Hospital
  Kansas City, Missouri, United States Recruiting

Study contacts

• Study coordinator: Winston M Manimtim, MD, FAAP
• Email: wmmanimtim@cmh.edu
• Phone: (816) 234-3592

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.