Using RxWell to Reduce Opioid Use After Knee or Hip Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot project evaluates the RxWell digital behavioral tool designed to support patients with mood disorders undergoing elective total knee or hip arthroplasty. The tool incorporates Cognitive Behavioral Therapy techniques and includes guidance from a behavioral health coach through in-app messaging. The study aims to assess the feasibility of using RxWell to improve mental health outcomes and reduce postoperative complications, opioid use, and healthcare resource utilization. Participants will be recruited from UPMC hospitals and will be monitored for improvements in anxiety and depression symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria for the RXWell Study:

* Adults \>18 years
* Scheduled for elective primary total knee arthroplasty (TKA) or hip replacement (THA) at the approved UPMC hospitals
* Moderately high levels of mood disorder symptoms on validated PROMIS measures, defined as a T-score \> or = to 60 on PROMIS Anxiety 4a short form and/or PROMIS Depression4a short form

Exclusion Criteria for the RXWell Study:

* Patients undergoing non-elective surgery or secondary arthroplasty
* Active delirium, neurocognitive impairment, or severe intellectual disability
* No access to a smart device (phone or tablet)
* Active alcoholism (defined as daily use of more than 1 liter of wine and /or 3 or more shots of hard liquor) or drug abuse (defined as daily use of illicit drugs)
* Profound mood disorders requiring immediate intervention such as suicidal ideation, defined as a PROMIS Depression score of more than 70
* A PROMIS Anxiety and/or Depression T-score \>70, which corresponds to severe anxiety and depression.

  * Patients needing immediate care will be referred to psychiatrists and primary team.

Where it's running

• UPMC East
  Monroeville, Pennsylvania, United States Recruiting
• UPMC Shadyside
  Pittsburgh, Pennsylvania, United States Recruiting
• UPMC Passavant
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Ata Murat Kaynar, MD, MPH — UPMC Department of Anesthesiology and Perioperative Medicine
• Study coordinator: Ata Murat Kaynar, MD, MPH
• Email: kaynarm@upmc.edu
• Phone: 412-383-3463

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.