EGR2 and NLRP3 pathways in sleep apnea-related thinking and mood problems

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll children (ages 2–18) and adults (>18) with obstructive sleep apnea-hypopnea syndrome (OSAS) alongside age- and sex-matched healthy volunteers. Children will undergo ENT examinations including nasal endoscopy and X-rays, while adults will receive overnight polysomnography; all participants will complete standardized sleepiness, mood, and cognitive questionnaires. Small blood draws will be collected from all participants and tiny adipose tissue samples obtained when available (for example during surgery) to measure EGR2 and NLRP3 pathway activity and inflammatory markers. Molecular data will be correlated with cognitive screening and mood scores to explore mechanisms linking intermittent hypoxia and inflammation to neurobehavioral symptoms in OSAS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Children aged 2-18 years with obstructive snoring or sleep apnea features on initial ENT outpatient screening.

Adults (\>18 years) with suspected OSAS in a sleep or respiratory clinic, presenting with chronic snoring, witnessed apneas, or daytime sleepiness, and without severe chronic heart, liver, kidney failure, psychiatric disorders, or pregnancy.

Signed written informed consent by the participant or their legal guardian. Not currently enrolled in any other registered clinical trial.

Exclusion Criteria:

Presence of congenital craniofacial malformations. Severe heart, lung, liver, or kidney failure, or major neurological disease. Recent use of anti-inflammatory or other immunomodulatory medications. Current psychiatric disorder or pregnancy

Where it's running

• Shanghai Xinhua hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Jiang, PHD,MD
• Email: jianglaimz@sina.com
• Phone: 13817719616

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.