Internet-based treatment for anxiety and depression in adolescents

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of a transdiagnostic Internet-delivered intervention for Romanian adolescents suffering from anxiety and depression. Participants aged 13-17 will undergo non-invasive fMRI scans to assess brain signal variability before being assigned to either the intervention or a control group. The study will also investigate the accuracy of a prediction model to determine which adolescents are likely to respond positively to the treatment. This is the first trial of its kind focusing on this demographic and utilizing fMRI data for treatment prediction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* elevated symptoms of anxiety or depression/ internalizing problems (T score\> 60) at intake (based on Youth self-report completed by adolescents)
* primary diagnosis of an anxiety/depressive disorder based on DSM-5 criteria according to ADIS-5-C/P interview
* age 13-17
* able to read and understand Romanian language
* Currently unmedicated or on stable and adequate doses of medication for at least 6 weeks before treatment onset
* Internet access

Exclusion Criteria:

* severe mental disorder (psychosis, severe depression, bipolar disorder, based on clinical interview)
* any condition that interferes with the protocol implementation (e.g., physical illness or sensory impairment that interferes with behavioral tasks such as exposure, behavioral activation, unavailable for the next 3 months),
* active suicidal ideation (assessed by child psychiatrist during clinical interview) in the last month
* currently following CBT/ psychotherapy for anxiety/depression, in the last 6 months
* fMRI incompatible (based on safety questionnaire)
* Being diagnosed with an intellectual disability, pervasive developmental disorder, an alcohol and/or substance dependence disorder, reading disabilities (based on clinical interview).
* Current treatment with benzodiazepines

Where it's running

• Babeș-Bolyai University
  Cluj-Napoca, Romania Recruiting
• Babes-Bolyai University
  Cluj-Napoca, Romania Not yet recruiting

Study contacts

• Study coordinator: Kristoffer Mansson, PhD
• Email: nils.mansson@ubbcluj.ro
• Phone: +46705803267

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.