Improving anxiety treatment while reducing benzodiazepine use in patients taking opioids

Augmenting the Efficacy of Benzodiazepine Taper with Telehealth-Delivered Cognitive Behavioral Therapy for Anxiety Disorders in Patients Using Prescription Opioids

NIH-funded research University of California Los Angeles · NIH-10705005

This study is looking for people who take both anxiety medications (benzodiazepines) and pain medications (opioids) to see if a special online therapy program can help them safely reduce their anxiety meds while also checking in on their pain and anxiety levels over 12 weeks.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of California Los Angeles NIH-funded
Lab location1 site (Los Angeles, United States)
Project IDNIH-10705005 on NIH RePORTER

What this research studies

This research investigates a new approach to help patients who are prescribed both benzodiazepines for anxiety and opioids for pain. It aims to safely taper off benzodiazepines using a telehealth-delivered cognitive behavioral therapy (CBT) program. Participants will be involved in a 12-week program where they will either receive CBT or health education while tapering their benzodiazepine dosage. The study will assess their benzodiazepine and opioid use, as well as anxiety symptoms, at various points during and after the treatment.

Who could benefit from this research

Good fit: Ideal candidates are patients who are currently prescribed both benzodiazepines and opioids for anxiety and pain management.

Not a fit: Patients who are not using benzodiazepines or opioids, or those with anxiety disorders not requiring medication, may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to safer treatment options for patients with anxiety disorders who are also using prescription opioids.

How similar studies have performed: Previous research has shown that cognitive behavioral therapy can effectively treat anxiety disorders, suggesting that this approach may also be beneficial in the context of tapering benzodiazepines.

Where this research is happening

Los Angeles, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Anxiety Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.