Expectancy Focused Exposure for Anxiety Disorders
Official title: Efficacy of Expectancy Focused Exposure Therapy in Reducing Fear and Preventing the Return of Anxiety Over Time: A Longitudinal Randomized Clinical Trial
Run by University of Chile · NCT07753330 · Data updated 2026-11-12
We test whether Expectancy Focused Exposure helps reduce anxiety symptoms and prevent fear from coming back better than Anxiety Focused Exposure in adults with anxiety disorders.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 203 (estimated) |
| Sponsor | University of Chile Academic / other |
| Locations | 1 site (Santiago, Santiago Metropolitan) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | July 30, 2028 |
| Study ends | March 31, 2029 |
| Registry record updated | August 7, 2026 |
| Trial ID | NCT07753330 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older with an anxiety disorder who are seeking psychological treatment.
✕Probably not a fit
Individuals without an anxiety disorder or those who do not respond to exposure-based therapies may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized approach compares two exposure-based therapies for adults with anxiety disorders, including social anxiety, specific phobia, generalized anxiety, and panic disorder. The study uses the inhibitory learning model to guide Expectancy Focused Exposure and contrasts it with Anxiety Focused Exposure. Participants undergo structured exposure sessions and are assessed on anxiety outcomes over time to see if fear returns less after EFE. Recruitment targets adults seeking treatment through university and community settings in Chile, with screening confirming DSM-5 diagnoses. The trial aims to determine if modifying expectancy during exposure provides longer-lasting relief than standard exposure.
Why it matters
Potential benefit: If successful, participants may experience longer-lasting reductions in anxiety and less relapse after treatment.
How similar studies have gone: Previous exposure-based therapies have shown benefits, but whether expectancy-focused modifications yield superior long-term outcomes is still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Population Description The study sample will consist of adult participants from the general population seeking psychological treatment for anxiety-related problems. Participants will be recruited through multiple sources, including university mental health services, student wellbeing units, community mental health centers, social media advertisements, and other public outreach channels. Recruitment will be intentionally broad to maximize accessibility and ecological validity. Screening and Selection Procedures Eligibility will be determined through a multi-stage screening process. Initial Screening: DSM-5 Cross-Cutting Measures, Levels 1 and 2 Participants responding to recruitment will first complete the DSM-5 Level 1 Cross-Cutting Symptom Measure (APA, 2013; Spanish version APA, 2014). This self-report instrument includes 23 items assessing 13 domains of psychopathology over the past 14 days using a 5-point Likert scale. It has shown good reliability and clinical utility in prior studies (APA, 2014; Bravo et al., 2018). Participants who meet threshold criteria for anxiety-related symptoms on the Level 1 measure will then complete the corresponding DSM-5 Level 2 anxiety measures to further characterize symptom severity. Disorder-Specific Symptom Assessment, Level 3 Participants who meet screening criteria on Levels 1 and 2 will complete disorder-specific symptom scales according to the anxiety disorder suspected or reported, including measures for social anxiety disorder, specific phobia, generalized anxiety disorder, and panic disorder with or without agoraphobia. Diagnostic Assessment Participants who remain eligible after the screening and disorder-specific symptom assessment will undergo a structured clinical interview using the Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5). The ADIS-5 will be used to establish the principal anxiety disorder diagnosis and to assess exclusion criteria, including psychotic disorder, bipolar disorder, high suicide risk, and severe or uncontrolled substance use disorder. Inclusion Criteria: Participants must meet all of the following criteria: * Age between 18 and 70 years. * Seeking treatment for anxiety-related difficulties. * Meet DSM-5 diagnostic criteria for a principal anxiety disorder, including: social anxiety disorder, specific phobia, generalized anxiety disorder, panic disorder with or without agoraphobia. * Diagnosis will be established using the ADIS-5 structured clinical interview. * For participants with generalized anxiety disorder, treatment will focus on the principal anxiety problem identified during assessment. * Present clinically significant anxiety symptoms associated with the principal diagnosis. * If currently taking anxiolytic medication, the dosage must have remained stable for at least three months before the start of treatment and should be maintained during the treatment phase whenever possible. * Willingness and ability to participate in weekly psychotherapy sessions and complete all study assessments. * Provide informed consent. Exclusion Criteria: Participants will be excluded if any of the following conditions are present: * Current psychotic disorder. * Current manic or hypomanic episode, consistent with bipolar disorder. * High suicide risk requiring immediate clinical intervention. * Severe or uncontrolled substance use disorder. * Concurrent participation in psychological treatment specifically targeting the anxiety disorder during the study period. * Medical conditions that contraindicate exposure procedures (e.g., severe cardiovascular conditions). * Cognitive impairment or insufficient language proficiency that would interfere with participation in psychotherapy or completion of assessments.
Where it's running
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Facultad de Ciencias Sociales, Universidad de Chile
Santiago, Santiago Metropolitan, Chile Recruiting
Study contacts
- Principal investigator: Vanetza E Quezada-Scholz, PhD — University of Chile
- Study coordinator: Vanetza E Quezada-Scholz, PhD
- Email: qvanetza@u.uchile.cl
- Phone: +56977361470
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.