Understanding who benefits most from different psychotherapies for depression and anxiety

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial examines predictors of response to three psychotherapy formats—individual therapy, group CBT, and internet-delivered CBT—in patients with depression and anxiety. Participants are allocated to one of these interventions, a delayed waitlist, or treatment as usual, with data collection aimed at identifying factors that influence treatment outcomes. The setting is IMH Singapore, leveraging routine referrals and triage to understand real-world applicability. The study will explore potential biological and psychosocial predictors that could guide right-siting and personalization of care. Recruitment targets all outpatients referred for psychotherapy at the institute who meet eligibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. For patients:

   1. 18-99 years old;
   2. have current or past symptoms of anxiety and/or depression;
   3. able to communicate and read in English;
   4. able to provide informed consent.
   5. Waitlist arm:

      \- Referred for psychotherapy but given a waiting time of 8 weeks or more to the first visit or not assigned to therapy at IMH.
   6. Treatment as usual:

      \- Not assigned to any psychotherapeutic interventions.
   7. iCBT: - Referred for iCBT;

      \- Identified as a 'P2' patient/appropriate for iCBT by triage.
   8. Group therapy:

      \- Referred for group therapy;

      \- Identified as a 'P2' patient/appropriate for group therapy by triage.
   9. Individual psychotherapy:

      * Referred for individual therapy;
      * Patient and therapist committed to frequent therapy (ideally fortnightly).
2. For therapists:

   1. Therapists who will see OR have been assigned to clients in the waitlist arm, iCBT, group therapy (e.g. PsychUp), and individual psychotherapy group.

Exclusion Criteria:

1\. For patients:

1. current active suicidal intention or plan;
2. cognitively-impaired/are unable to consent/lack capacity to consent.

Where it's running

• Institute of Mental Health, Singapore
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Geoffrey CY Tan — Institute of Mental Health, Singapore
• Study coordinator: Geoffrey CY Tan
• Email: geoffrey_tan@imh.com.sg
• Phone: +65 63891923

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.