Clinical trial Recruiting at 1 site Interventional Ages 14 to 19

Developing a group treatment to help teens at risk for serious mental illness

Official title: Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Run by Massachusetts General Hospital · NCT05962879 · Data updated 2026-11-12

This study is testing a new group program to help high school students with mild signs of depression or anxiety build resilience and prevent serious mental health issues.

Quick facts

Study typeInterventional
Ages14 Years to 19 Years
SexAll
Enrollment70 (estimated)
SponsorMassachusetts General Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedMarch 22, 2024
Main results expectedMay 31, 2027
Study endsMay 31, 2027
Registry record updatedJune 11, 2026
Trial IDNCT05962879 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are high school students aged 14 to 19 who have experienced at least one psychotic experience and are willing to participate with parental consent.

Probably not a fit

Patients currently on psychotropic medications or receiving psychotherapeutic interventions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to create a brief group-based treatment called Resilience Training for Teens, designed to support high school students who exhibit mild symptoms of depression, anxiety, or unusual feelings. The intervention will be tested to evaluate its effectiveness in preventing the development of serious mental illnesses among adolescents. Participants will be enrolled from grades 9 to 12 and will engage in group sessions focused on building resilience and coping strategies.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce the risk of serious mental illness in adolescents.

How similar studies have gone: Other studies have shown promise in using resilience training and similar interventions for mental health, indicating potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Currently enrolled in 9th through 12th grade and between the ages of 14 and 19
* Endorsed at least one psychotic experience
* Provided contact information
* Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18)
* Have a parent or legal guardian who is able and willing to participate in a parent session
* Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older)
* Able to communicate in English

Exclusion Criteria:

* Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence
* Currently obtaining psychotherapeutic intervention

Where it's running

  • Massachusetts General Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.