Developing a group treatment to help teens at risk for serious mental illness
Official title: Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Run by Massachusetts General Hospital · NCT05962879 · Data updated 2026-11-12
This study is testing a new group program to help high school students with mild signs of depression or anxiety build resilience and prevent serious mental health issues.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 19 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | March 22, 2024 |
| Main results expected | May 31, 2027 |
| Study ends | May 31, 2027 |
| Registry record updated | June 11, 2026 |
| Trial ID | NCT05962879 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are high school students aged 14 to 19 who have experienced at least one psychotic experience and are willing to participate with parental consent.
✕Probably not a fit
Patients currently on psychotropic medications or receiving psychotherapeutic interventions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to create a brief group-based treatment called Resilience Training for Teens, designed to support high school students who exhibit mild symptoms of depression, anxiety, or unusual feelings. The intervention will be tested to evaluate its effectiveness in preventing the development of serious mental illnesses among adolescents. Participants will be enrolled from grades 9 to 12 and will engage in group sessions focused on building resilience and coping strategies.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce the risk of serious mental illness in adolescents.
How similar studies have gone: Other studies have shown promise in using resilience training and similar interventions for mental health, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Currently enrolled in 9th through 12th grade and between the ages of 14 and 19 * Endorsed at least one psychotic experience * Provided contact information * Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18) * Have a parent or legal guardian who is able and willing to participate in a parent session * Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older) * Able to communicate in English Exclusion Criteria: * Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence * Currently obtaining psychotherapeutic intervention
Where it's running
-
Massachusetts General Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Study coordinator: Nicole R DeTore, PhD
- Email: ndetore@mgh.harvard.edu
- Phone: 617-726-2065
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Understanding anxiety, depression, and bipolar disorder over time in China
This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.
-
Parent group program using the Unified Protocol for teens with autism and anxiety/depression
This trial tests a parent-guided adaptation of the Unified Protocol to help adolescents with autism and co-occurring anxiety or depression.
-
Digital stepped-care mindfulness program for emotional disorders
This project tests whether adding an online mindfulness program to usual care helps adults (18–65) with depression, anxiety, OCD, or PTSD recover faster and stay well longer.
-
Comparing brief psychoanalytic and emotionally focused couple therapies for relationship distress
This trial will test whether brief psychoanalytic couple therapy or emotionally focused therapy better reduces relationship problems and related depression and anxiety in heterosexual couples with moderate to severe relationship distress.
-
Preventive behavioral intervention for young adults with psychotic experiences
This study is testing if a new Resilience Training program can help college freshmen and sophomores who are at risk for serious mental illnesses feel better and prevent issues like psychosis, mood swings, and anxiety.
-
Comparing Islamic and Standard Hypnotherapy for Anxiety and Depression
This study is testing whether a special type of hypnotherapy that incorporates Islamic principles can help Muslim adults with anxiety and depression feel better compared to standard hypnotherapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.