Preventive behavioral intervention for young adults with psychotic experiences

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of Resilience Training in college students who are at an elevated risk for developing serious mental illnesses. Participants, aged 18-30 and enrolled as freshmen or sophomores, will be randomly assigned to receive either Resilience Training or Life Skills Training. The study aims to assess how these interventions can help mitigate the onset of psychotic disorders, mood disorders, and anxiety disorders in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. 18-30 years old
2. Enrolled as a first or second year student (i.e., freshman or sophomore) in an undergraduate program at the college or university where the intervention takes place
3. Students who endorse some psychotic experiences (Peter's et al. Delusion Inventory (PDI) score \> 3)

Exclusion criteria:

1. Inability to provide informed consent
2. Not proficient in English
3. Current self-reported Diagnostic Statistical Manual 5 (DSM-5) diagnosis with active symptoms (such as active psychotic symptoms, current suicidality, serious active alcohol or substance use, marked deterioration in functioning over the prior month) determined by clinical interview with participant, or self-report of a psychiatric diagnosis that necessitates close monitoring or individual therapy and/or inpatient or partial hospitalization
4. Current enrollment in psychological or behavioral health treatment.
5. Current use of psychotropic medications (other than stimulants) prescribed by a physician.
6. A diagnosis of a serious, chronic mental illness as determined by the Mini-International Neuropsychiatric Interview (MINI)

Where it's running

• Massachusetts General Hospital
  Charlestown, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Daphne J Holt, MD, PhD
• Email: dholt@mgh.harvard.edu
• Phone: 617-726-7618

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating personalized medication based on genetic testing for psychiatric disorders

  This study is testing if giving personalized medication advice based on your genes can help people with mood, anxiety, or psychotic disorders feel better compared to regular medication dosing.

  Recruiting at 8 sites Parnassia Groep · Syracuse, New York and 8 other locations · NCT05656469

• Understanding sensory profiles of patients using a calming room

  This study looks at how patients in a psychiatric hospital respond to different senses before and after using a calming room to see if their sensory experiences affect their mental health.

  Recruiting Centre Hospitalier Esquirol · Limoges, New Aquitaine · NCT06839950

• Cognitive Behavioural Therapy for youth with mood and anxiety disorders

  This study is testing a new type of Cognitive Behavioural Therapy called CBT-MyOWL for young people aged 14-19 with mood and anxiety disorders to see if it helps them stick with treatment and feel better compared to standard therapy.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT06532500

• Developing a group treatment to help teens at risk for serious mental illness

  This study is testing a new group program to help high school students with mild signs of depression or anxiety build resilience and prevent serious mental health issues.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05962879

• Combining neurostimulation with emotion regulation training for emotional issues

  This study is testing if combining brain stimulation with training on how to manage emotions can help people with emotional issues feel better.

  Recruiting Duke University · Durham, North Carolina · NCT05712057

• Using RxWell to Reduce Opioid Use After Knee or Hip Surgery

  This study is testing whether a digital tool called RxWell can help people with mood disorders who are having knee or hip surgery reduce their opioid use and improve their mental health after the operation.

  Recruiting at 3 sites University of Pittsburgh · Monroeville, Pennsylvania and 2 other locations · NCT05658796

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.