Improving therapy for veterans with PTSD and anxiety
Enhancing Intensive Transdiagnostic Cognitive Behavioral Therapy for Veterans With PTSD and Anxiety Disorders
This study is testing whether individual or group therapy can help veterans and service members with PTSD and anxiety feel better compared to regular care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 306 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT05843695 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare two intensive formats of cognitive-behavioral therapy (CBT) for veterans and service members suffering from PTSD and anxiety disorders. Participants will be randomly assigned to receive either individual or group intensive CBT, or usual care, over a short period. The study will assess the effectiveness of these formats in improving anxiety symptoms and overall quality of life. Additionally, non-responders will receive extra individual therapy sessions to enhance treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates include veterans or service members aged 18 and older with a current diagnosis of an anxiety-based disorder and moderate-to-poor life satisfaction.
Not a fit: Patients with active symptoms of mania, psychosis, or severe cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and accessible treatment options for veterans and service members with PTSD and anxiety disorders.
How similar studies have performed: Other studies have shown promise in using intensive CBT formats for treating anxiety disorders, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Veteran/Service Member at least 18 years old * Current diagnosis of at least one anxiety-based disorder: Posttraumatic Stress Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Other Specified Trauma- and Stressor-Related Disorder, Other Specified Anxiety Disorder, and Unspecified Anxiety Disorder (based on ADIS-5) * Moderate-to-poor life enjoyment and satisfaction as indicated by a score of 47 or lower on the QLES-Q-SF * Stable on psychotropic medication for 4 weeks before study participation * Willing to be randomized to treatment condition Exclusion Criteria: * Active symptoms of mania or psychosis at baseline (based on ADIS-5) * Depression with active suicidal ideation and intent that would preclude treatment (based on ADIS-5 \& BDI-II) * Moderate-to-severe cognitive impairment as indicated by the SLUMS (a score below 20) * Veterans/Service Members with comorbid substance/alcohol use or dependence are study eligible but must agree to reduce and limit their use of substances during the active course of treatment, particularly during exposure exercises. If they do not agree to this, they will be excluded * Undergoing concurrent transdiagnostic CBT specifically targeting any of the above-mentioned disorders
Where this trial is running
Houston, Texas
- Michael E. DeBakey VA Medical Center — Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Ellen Teng, PhD — Michael E. DeBakey VA Medical Center
- Study coordinator: Ellen Teng, PhD
- Email: eteng@bcm.edu
- Phone: (713) 791-1414
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.