Identifying genetic markers for SSRI-induced behavioral activation in youth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify and validate genetic markers associated with behavioral activation caused by selective serotonin reuptake inhibitors (SSRIs) in children and adolescents diagnosed with major depressive disorder, anxiety disorders, or obsessive-compulsive disorder. By analyzing participants who have experienced adverse effects from SSRIs, the study seeks to develop clinically useful markers that can predict which patients are at risk for these side effects. The ultimate goal is to improve health outcomes and reduce the incidence of behavioral activation in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion criteria: Participants will be eligible for participation if all of the following are true.

* Resident of Manitoba
* Age, 6 - 24 years
* Diagnosis of major depressive disorder (MDD), anxiety disorder, or obsessive-compulsive disorder (OCD)
* Current or past history of selective serotonin reuptake inhibitor (SSRI), e.g., Citalopram \[Celexa\], Escitalopram \[Cipralex\], Fluoxetine \[Prozac\], Fluvoxamine \[Luvox\], Sertraline \[Zoloft\], Paroxetine \[Paxil/Plaxil CR\]) therapy
* \[Cases Only\] Have experienced behavioural side effects after taking an SSRI that resolved after reducing the dose or discontinuation of the drug
* \[Controls Only\] Did not experience any side effects after taking an SSRI for eight (8) continuous weeks

Exclusion criteria: Participants will be excluded from participation if any of the following are true.

* Inability of parent/legal guardian/mature minors to give informed consent
* Inability of the child (6 - 13 years) to give informed assent
* Unwillingness of the child to provide a saliva sample for genetic analysis
* Current, past, or suspected diagnosis of attention deficit hyperactivity disorder (combined or hyperactive type), oppositional defiant disorder, conduct disorder, bipolar disorder, psychotic disorder, pervasive developmental disorder
* History of liver or bone marrow (hematopoietic cell) transplant.

Where it's running

• Shared Health Facilities
  Winnipeg, Manitoba, Canada Recruiting
• University of Manitoba College of Pharmacy
  Winnipeg, Manitoba, Canada Recruiting

Study contacts

• Study coordinator: Abdullah A Maruf, BPharm, MPharm, PhD
• Email: abdullah.maruf@umanitoba.ca
• Phone: 204-318-2575

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.