Condition

Depression Disorders clinical trials and research

• 24Clinical trials
• 2NIH research projects
• 15Countries

Newest Depression Disorders clinical trials

All recruiting trials (24)

• Medical and psychiatric profiling of adults admitted to general adult psychiatry wards

  This project will collect questionnaires, rating scales, and case-note information from adults admitted to general adult psychiatry wards to see what their physical and mental health profiles look like.

  Recruiting University of Edinburgh · Livingston, West Lothian · NCT07398365

• Long-term psychotropic medication effects on eye movements measured with the Gaize VR headset

  This project will test whether the Gaize VR headset can detect eye-movement patterns associated with long-term use of prescribed psychotropic medications in adults.

  Recruiting Gaize · Philadelphia, Pennsylvania · NCT07389473

• Psychiatric Symptoms and Quality of Life in Graft-versus-Host Disease

  This project will see if psychiatric symptoms like depression are linked to GvHD symptom severity and health-related quality of life in adults with graft-versus-host disease.

  Recruiting Medical University of Gdansk · Gdansk, Pomeranian Voivodeship · NCT07314892

• Digital twins to classify mental health patterns in adults with diabetes

  This project will try to create 'digital twin' profiles that combine glucose, mood, and behavior data to track mental health patterns in adults with diabetes.

  Recruiting Forschungsinstitut der Diabetes Akademie Mergentheim · Bad Mergentheim, Baden-Wurttemberg and 2 other locations · NCT07212075

• Fluoxetine added to immunotherapy for advanced liver and gallbladder cancer with depression or anxiety

  This trial will test whether adding the antidepressant fluoxetine to standard PD-1/PD-L1 immunotherapy helps people with advanced liver or gallbladder cancers who also have depression or anxiety.

  Recruiting Phase 2 First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07174947

• Teen Recovery: Inspiration, Support, and Empowerment program

  This pilot will test whether an online peer-led recovery and support program helps 15–18-year-olds recently discharged from psychiatric care reduce suicidal thoughts, depression, anxiety, and re-hospitalization.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07170657

• Beta-band brain stimulation to reduce impulsive self-injury in teens

  This trial will try twice-daily beta-frequency transcranial alternating current stimulation versus sham in adolescents with non-suicidal self-injury to see if it reduces self-harm episodes and impulsivity and is safe.

  Recruiting Anhui Medical University · Hefei, Anhui · NCT07152925

• CONNECT program: group telehealth to reduce loneliness and improve mental health in adults 55+

  This project will test whether the group-based CONNECT telehealth program can reduce loneliness, social isolation, anxiety, and depression in adults 55 and older compared with routine community programming.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT07107906

• Heated yoga, sauna, or a mindfulness app for depression

  This project will test whether heated yoga, sauna sessions, or a mindfulness app reduce symptoms in adults with at least moderate depression.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07082998

• Unified Protocol for emotional disorders in prison groups

  This study tests the Unified Protocol in group sessions to help inmates with anxiety, depression, and related mood issues.

  Recruiting Instituto de Investigación Sanitaria Aragón · Manresa, Catalonia and 1 other locations · NCT07070531

• Narrative Exposure Therapy for Ukrainian refugees in Norway

  This project will try Narrative Exposure Therapy delivered by trained Ukrainian health workers to see if it reduces PTSD and depression symptoms in Ukrainian refugees living in Norway.

  Recruiting Kristiania University College · Oslo · NCT07062042

• Recovery Through Inspiration, Support, and Empowerment for Young Adults

  This pilot will try peer-led one-on-one and small-group recovery support for 18–27-year-olds recently discharged from acute psychiatric care to help reduce suicidal thoughts, depression, anxiety, and rehospitalizations.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07051200

• Therapeutic effects of Well-Being Therapy for chronic insomnia with depression

  This study is testing if Well-Being Therapy can help people with chronic insomnia and depression feel better after six sessions of treatment.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT06968013

• Online treatment for emotional disorders in adults with long COVID-19

  This study is testing if an online treatment for emotional issues can help adults with long COVID-19 feel better compared to regular care.

  Recruiting Instituto de Investigación Sanitaria Aragón · Zaragoza, Zaragoza and 1 other locations · NCT06928480

• AI-COA®: using AI to measure depression and anxiety severity from video interviews

  This will test whether an AI tool can reliably measure depression and anxiety severity from video interviews in adults who have just started a new treatment.

  Recruiting Deliberate Solutions Inc. · Houston, Texas · NCT06923995

• Couples' Affect in Relationships: Testing a Well-Being App for Couples

  We’re testing whether using a well-being mobile program with one partner in a long-term relationship can improve both partners’ happiness and relationship satisfaction.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06907654

• Evaluating visual rehabilitation's effects on anxiety and depression in patients with AMD

  This study is testing whether a visual rehabilitation program can help reduce anxiety and depression in people with advanced age-related macular degeneration.

  Recruiting Fondazione G.B. Bietti, IRCCS · Rome, Italy · NCT06906003

• Improving patient engagement in collaborative care for anxiety and depression

  This study is testing a new way to involve patients more in their anxiety and depression treatment by using their personal goals to see if it makes them and their doctors happier with the care they receive.

  Recruiting at 6 sites Dartmouth-Hitchcock Medical Center · Concord, New Hampshire and 5 other locations · NCT06898593

• CYB003, a deuterated psilocin, for adults with major depressive disorder

  This trial will test whether adding CYB003 to a current antidepressant helps reduce symptoms in adults with major depressive disorder who have not responded well to their medication.

  Recruiting at 51 sites Phase 3 Cybin IRL Limited · Birmingham, Alabama and 78 other locations · NCT06793397

• Improving PTSD treatment through patient engagement strategies

  This study is testing if adding extra support like motivation sessions and shared decision-making can help people with PTSD stick with their treatment and feel better compared to standard care.

  Recruiting Herlev and Gentofte Hospital · Ballerup Municipality, Capital Region · NCT06755710

• Improving self-efficacy to prevent mental disorders in young adults

  This study is testing if a special training program can boost confidence in young adults aged 18-30 to help prevent mental health issues like anxiety and substance use.

  Recruiting Health and Medical University Potsdam · Potsdam, Brandenburg · NCT06738953

• Online group therapy program for anxiety, depression, and related problems

  This trial tests a new online group therapy based on the Unified Protocol, delivered by video call and a companion website, for adults on NHS waiting lists with anxiety, depression, or related problems.

  Recruiting Rotherham Doncaster and South Humber NHS Foundation Trust · Doncaster, South Yorkshire and 1 other locations · NCT06722781

• Assessing depression levels in cardiothoracic surgery healthcare workers in Baghdad

  This study is trying to see how common and severe depression is among healthcare workers in heart and lung surgery in Baghdad and if their job stress affects their mental health.

  Recruiting Al-Nahrain University · Baghdad · NCT06702761

• Meditative neurofeedback for treating depression

  This study is testing whether a new 10-session meditation program using neurofeedback can help people with major depression feel better.

  Recruiting Phase 1 University of California, San Diego · La Jolla, California · NCT06675240

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Suicide risk in bipolar disorder and major depression

  This project uses brain scans and questionnaires to find brain circuit and metabolic differences linked to suicidal behavior in people with bipolar disorder or major depression.

  NIH research University of Iowa · Iowa City, United States · NIH-11137744

• Understanding suicidality in bipolar disorder and major depression

  This study is looking at how certain brain connections might be linked to suicidal thoughts and behaviors in people with bipolar disorder and major depression, and it’s for individuals who have experienced suicidal thoughts or attempts, as well as those without such experiences.

  NIH research University of Iowa · Iowa City, United States · NIH-10880656

Related topics

Quick answers

How many Depression Disorders clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (9 trials), United Kingdom (3 trials), China (3 trials), Germany (3 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →