Adductor canal plus IPACK block versus adductor canal block alone for pain control after HTO/DFO/TTO

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind, single-center Phase 4 trial compares combined adductor canal block (ACB) plus IPACK infiltration to isolated ACB in adults undergoing high tibial osteotomy (HTO), distal femoral osteotomy (DFO), or tibial tubercle osteotomy (TTO). Participants aged 18–75 with ASA I–II are randomized to receive either ACB+IPACK or ACB alone, with patients blinded to allocation. The primary outcomes are postoperative pain scores and opioid consumption monitored in the immediate postoperative period and during early follow-up. Key exclusions include chronic opioid use, multi-ligament injuries, concomitant cartilage procedures or ACL reconstruction, significant organ disease, and neurologic or cognitive conditions that affect pain reporting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients between 18 and 75 years of age
* Patients undergoing HTO/DFO/TTO.
* American Society of Anesthesiologists (ASA) I or II

Exclusion Criteria:

* Patients younger than 18 and older than 75.
* Patients with multi-ligament injury
* Patients undergoing concomitant cartilage procedure or ACLR.
* Patients with a history of chronic pain that have used opioids for pain management for 3 months or longer.
* Patients who are allergic to oxycodone;
* Patients with diagnosed or self-reported cognitive dysfunction;
* Patients with a history of neurologic disorder that can interfere with pain sensation;
* Patients with a history of drug or recorded alcohol abuse;
* Patients who are unable to understand or follow instructions;
* Patients with severe liver disease, renal insufficiency, congestive heart failure, and/or significant heart disease;
* Patients with an allergy or contraindication to any of the medications used in the study, or patients with a contraindication to any study procedures;
* Patients with a BMI over 45;
* Any patient that the investigators feel cannot comply with all study related procedures;
* Any pregnant patient; assessed via urine pregnancy test in the preoperative area as part of standard preoperative surgical protocol;

Where it's running

• NYU Langone Health
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Laith Jazrawi, MD — NYU Langone Health
• Study coordinator: Laith Jazrawi, MD
• Email: Laith.jazrawi@nyulangone.org
• Phone: 646-501-7223

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.