Finding new ways to relieve pain without dangerous side effects
Identification of allosteric molecules for DOR-KOR heteromer-mediated peripheral analgesia
This study is exploring new ways to relieve pain without the harmful side effects of opioids, aiming to find safer treatments that work directly on the nerves that sense pain, so people can feel better without the risk of addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10914772 on NIH RePORTER |
What this research studies
This research focuses on developing new pain relief methods that avoid the dangerous side effects associated with traditional opioid medications. The team is investigating a specific receptor combination in pain-sensing neurons that, when activated, can provide effective pain relief. By identifying small molecules that can selectively activate these receptors, the research aims to create safer analgesic drugs that target pain at its source. This approach could lead to innovative treatments that help manage pain without the risk of addiction or respiratory issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who experience nociceptive pain and are seeking alternative pain management options.
Not a fit: Patients who do not experience pain or have conditions unrelated to nociceptive pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer pain relief medications that minimize the risk of addiction and other severe side effects.
How similar studies have performed: Previous research has shown promise in targeting receptor combinations for pain relief, indicating that this approach could be a viable alternative to traditional analgesics.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Clarke, William P — University of Texas Hlth Science Center
- Study coordinator: Clarke, William P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.