Personalized perioperative pain prevention for high-risk patients
Official title: Personalizing Perioperative Preventive Analgesia: Translational Studies Investigating the Biopsychosocial Underpinnings of Enhanced Pain Propensity
Funded at Stanford University · NIH-11398276 · Data updated 2026-11-12
A research program at Stanford is exploring why some people have long-lasting pain after surgery and how to prevent it in patients who are most at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $437,163 |
| NIH project number | 5R35GM128691-10 |
| Project ID | NIH-11398276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients scheduled for surgery who are at risk for developing PPSP based on identified risk factors.
✕Less likely to help
Patients without risk factors for PPSP or those not undergoing surgery may see no direct benefit.
What this research studies
This project follows patients before, during, and after various surgeries to identify who is likely to develop persistent post-surgical pain. It uses a human model to study how pain signals are amplified and how biology, psychology, and social factors contribute to pain after surgery. The goal is to translate basic science findings into practical strategies to prevent PPSP in people undergoing surgery. The work combines longitudinal assessments, psychophysics, and clinical observations to pinpoint risk factors and potential prevention targets.
Why it matters
Potential benefit: If successful, the research could lead to personalized strategies to reduce long-term post-surgical pain and opioid exposure for high-risk patients.
How similar studies have gone: Previous work has shown risk factors and mechanisms in PPSP, but translating these findings into prevention has been challenging and this study aims to advance that translation.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Schreiber, Kristin — Stanford University
- Study coordinator: Schreiber, Kristin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.