Single-dose IV magnesium sulfate to reduce pain after laparoscopic gallbladder removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-arm trial enrolling 106 adults aged 18–65 with ASA physical status I–II who are scheduled for elective laparoscopic cholecystectomy. Participants are randomized to receive a single IV dose of magnesium sulfate (30 mg/kg in 100 ml normal saline) or placebo (normal saline) alongside standard anesthetic care. The primary outcome is total postoperative morphine consumption, with secondary outcomes including pain scores (VAS), time to first rescue analgesia, hemodynamic responses, and adverse events. Data will be compared between groups using descriptive statistics, chi-square tests, and t-tests or Mann–Whitney U-tests as appropriate.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age - 18 - 65 years, either sex American Society of Anesthesiologists (ASA) Physical status classification system group I and II Elective laparoscopic cholecystectomy

Exclusion Criteria:

Patient refusal BMI \> 30 kg/m² OSA Renal, hepatic or cardiovascular dysfunction including cardiac conduction disorders Those on long term calcium channel blockers or receiving magnesium supplements Opioid or analgesic abuse Psychiatric illness Surgical duration \< 1 h \& \> 3 h Lap converted to open

Where it's running

• Tata Main Hospital
  Jamshedpur, Jharkhand, India Recruiting
• Dr.Deb Sanjay Nag
  Jamshedpur, Jharkhand, India Recruiting

Study contacts

• Study coordinator: Dr Deb Sanjay Nag, MD
• Email: debsanjay@gmail.com
• Phone: 9431166582

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.