Comparing dexmedetomidine and dexamethasone for pain relief in thyroid surgery
Official title: Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Ultrasound-guided Intermediate Cervical Plexus Block in Patients Undergoing Thyroidectomy
Run by Damanhour Teaching Hospital · NCT05793060 · Data updated 2026-11-12
This study is testing whether adding dexmedetomidine or dexamethasone to a pain relief shot helps people having thyroid surgery feel less pain and recover faster.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Damanhour Teaching Hospital Government |
| Locations | 1 site (Damanhūr, El-Beheira) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | December 1, 2027 |
| Study ends | December 15, 2027 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT05793060 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 21 to 60 with an ASA physical status of II or lower, who are scheduled for total thyroidectomy.
✕Probably not a fit
Patients with significant comorbidities, such as severe respiratory or cardiac conditions, or those with thyroid malignancy, are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the safety and effectiveness of dexmedetomidine versus dexamethasone as adjuvants to bupivacaine in ultrasound-guided intermediate cervical plexus block for patients undergoing total thyroidectomy. The study involves 60 patients who will be randomly assigned to receive either dexmedetomidine or dexamethasone alongside bupivacaine to enhance pain management during and after surgery. The goal is to determine which adjuvant provides better analgesia and contributes to quicker recovery and discharge from the hospital.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing thyroid surgery, potentially reducing postoperative pain and hospital stay.
How similar studies have gone: Previous studies have shown promising results with similar adjuvant approaches in nerve blocks, indicating potential for success in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 to 60 years * Body Mass Index (BMI) ≤ 35 kg/m2 Exclusion Criteria: * ASA physical status \> II * Age \< 21 years or \> 50 years * BMI \> 35 kg/m2 * Bronchial asthma * Chronic obstructive pulmonary disease * Restrictive lung diseases * Sick sinus syndrome * Sinus bradycardia * Hypertension * Chronic hypotension * Ischemic heart disease * Coagulopathies * Hepatic insufficiency * Renal insufficiency * Diabetes mellitus * Peripheral neuropathy * Thyroid malignancy * Hyperthyroidism * Substernal goiter * Patients on beta-blockers * Patients using pacemakers * Alcohol or drug abuse * Allergy to the study drugs
Where it's running
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Damanhour Teaching Hospital
Damanhūr, El-Beheira, Egypt Recruiting
Study contacts
- Principal investigator: Ahmed M Shaat, MD — Damanhour Teaching Hospital
- Study coordinator: Ahmed M Shaat, MD
- Email: ahmedshaat99@gmail.com
- Phone: 00201223482709
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.