Clinical trial Recruiting at 1 site Interventional Ages 18 to 75

Analgesia after total hip replacement using SA-QLB vs PENG block

Official title: A Randomized Clinical Non-Inferiority Trial Comparing Supra-Iliac Anterior Quadratus Lumborum Block and Pericapsular Nerve Group (PENG) Block for Analgesia After Total Hip Arthroplasty

Run by Tanta University · NCT07606794 · Data updated 2026-11-12

This study tests whether the SA-QLB or the PENG block provides better pain relief for adults having a total hip replacement.

Quick facts

Study typeInterventional
Ages18 Years to 75 Years
SexAll
Enrollment50 (estimated)
SponsorTanta University
Academic / other
Locations1 site (Tanta, El-Gharbia)
StatusRecruiting
StartedMay 23, 2026
Main results expectedOctober 30, 2026
Study endsOctober 30, 2026
Registry record updatedJune 23, 2026
Trial IDNCT07606794 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–75 undergoing primary unilateral THA under spinal anesthesia without contraindications to regional blocks and without the listed exclusions.

Probably not a fit

Patients with contraindications to regional anesthesia, opioid dependence, BMI > 40 kg/m2, or other exclusion criteria may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two regional anesthesia techniques—the supra-iliac anterior quadratus lumborum block and the pericapsular nerve group block—in patients undergoing unilateral primary THA under spinal anesthesia. It aims to determine which block offers superior analgesia and potentially reduces opioid needs after surgery. Eligible adults are 18 to 75 years old, with ASA I–III, scheduled for elective THA, and without contraindications to regional anesthesia. The trial uses ultrasound guidance to perform the blocks and administers standard perioperative care.

Why it matters

Potential benefit: If successful, the preferred block could provide better pain control and may lessen opioid consumption after hip replacement.

How similar studies have gone: Previous regional anesthesia approaches for THA have shown promising analgesia, but direct comparisons between SA-QLB and PENG block are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age from 18 to 75 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) classification I-III.
* Scheduled for primary elective unilateral total hip arthroplasty (THA) under spinal anesthesia.

Exclusion Criteria:

* Known allergies to the drugs used.
* Infection at the injection site.
* Bleeding disorders.
* Recognized neuromuscular disorders.
* Opioid addiction or dependence.
* Contraindications to regional anesthesia or peripheral nerve blockade.
* Body mass index (BMI) \> 40 kg/m².
* Associated decompensated cardiac, hepatic, respiratory, or renal diseases.

Where it's running

  • Tanta University
    Tanta, El-Gharbia, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.