Esmolol vs Dexmedetomidine for opioid-sparing in laparoscopic gynecologic surgery
Official title: The Impact of Intraoperative Esmolol and Dexmedetomidine Administration on Opioid Consumption in Laparoscopic Gynecological Procedures: A Double-blinded Randomized Study
Run by National and Kapodistrian University of Athens · NCT07846722 · Data updated 2026-11-12
This study tests whether low-dose esmolol or dexmedetomidine, given during surgery, reduces opioid use and improves pain control after laparoscopic hysterectomy compared with placebo.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 70 Years |
| Sex | Women only |
| Enrollment | 90 (estimated) |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Athens) |
| Status | Recruiting |
| Started | July 15, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | February 1, 2027 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT07846722 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult patients (ASA I–II) undergoing laparoscopic hysterectomy without contraindications to esmolol, dexmedetomidine, or the study anesthetic regimen.
✕Probably not a fit
Patients with complex health conditions, higher surgical risk, or specific exclusions may not experience opioid-sparing benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, placebo-controlled trial compares three parallel groups receiving intraoperative esmolol, dexmedetomidine, or placebo under standardized TIVA and postoperative PCA analgesia in adults undergoing laparoscopic hysterectomy. The goal is to assess intraoperative and postoperative opioid requirements and overall analgesic efficacy, with attention to recovery quality. Participants are adults with ASA I–II undergoing this procedure, excluding those with significant comorbidity or contraindications to study drugs. The study aims to determine if esmolol can provide opioid-sparing effects similar to dexmedetomidine, potentially offering a favorable recovery profile. The lead institution is Alexandra General Hospital in Athens, with Vasiliki Samartzi as lead sponsor.
Why it matters
Potential benefit: If successful, patients could experience less opioid use and better recovery after surgery.
How similar studies have gone: Prior evidence supports opioid-sparing effects of both drugs, but direct head-to-head data in this surgical context are limited and the approach is being tested prospectively.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients * American Society of Anesthesiologists (ASA) classification I-II * Laparoscopic hysterectomy Exclusion Criteria: * body mass index (BMI) \>35 kg/m2 * β-blocker administration preoperatively * systematic use of analgesic agents preoperatively * chronic pain syndromes preoperatively * neurological or psychiatric disease on treatment * pregnancy * severe hepatic or renal disease * history of cardiovascular diseases/ arrhythmias/ conduction abnormalities * hemodynamic instability * patients with a known malignancy or undergoing surgery for oncological reasons * known allergy to a local anesthetic * drug or alcohol abuse * language or communication barriers * lack of informed consent
Where it's running
-
"Alexandra" General Hospital
Athens, Greece Recruiting
Study contacts
- Study coordinator: Vasiliki Samartzi
- Email: v.samartzi2@gmail.com
- Phone: +30 6939001517
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.