Three nerve blocks for knee replacement: which one works best

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind study, 141 adults undergoing unilateral total knee replacement are assigned to one of three levobupivacaine nerve block protocols to compare analgesic effectiveness. The primary outcome is postoperative pain control, with secondary outcomes including range of motion, flexion, medication use, and potential differences by sex and age. Participants are followed for the first 3 days of hospitalization and then via a 30-day telephone check-in. Data are collected on a standardized case report form and analyzed to determine if one block offers superior analgesia and functional outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Total Knee prosthesis
* ASAC I-II
* signed Informed consent form

Exclusion Criteria:

* \<40 years
* Mental confusion and delirium
* Coagulation disorders

Where it's running

• IRCCS Galeazzi Milano
  Milan, Michigan, Italy Recruiting
• Ospedale Galeazzi S.p.A.
  Milan, Italy, Italy Completed

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.