Investigating how a specific factor from stem cells can reduce dental pain.

Who could benefit from this research

What this research studies

This research explores the potential of human Stem Cells of Apical Papilla (hSCAP) to alleviate dental pain caused by apical periodontitis. The study aims to understand how these stem cells can inhibit pain signals in the nervous system, specifically targeting trigeminal neurons involved in pain perception. By using advanced techniques like CRISPR-Cas9 to modify stem cells and testing their effects in both laboratory and animal models, the research seeks to uncover the mechanisms behind stem cell-induced pain relief.

Why it matters

Where this research is happening

• University of Texas Hlth Science Center
  San Antonio, United States Active

Researchers

• Principal investigator: Ruparel, Nikita — University of Texas Hlth Science Center
• Study coordinator: Ruparel, Nikita

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.