Investigating how repeated CBD use affects cannabis addiction and pain relief

Effects of Repeated CBD Administration on Cannabis Abuse-Liability and Analgesia: A Human Laboratory Study

NIH-funded research Columbia University Health Sciences · NIH-10663671

This study is looking at how different amounts of CBD can affect the experience of smoking cannabis and help with pain relief for healthy adults who already use cannabis.

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10663671 on NIH RePORTER

What this research studies

This research explores the effects of cannabidiol (CBD) on cannabis use and pain relief in healthy adult cannabis smokers. Participants will receive varying doses of CBD over 15 days while smoking cannabis in a controlled laboratory setting. The study aims to measure the impact of CBD on the subjective effects of cannabis and its potential to enhance pain relief. By understanding these interactions, the research seeks to provide insights into the therapeutic use of cannabis and CBD for managing pain.

Who could benefit from this research

Good fit: Ideal candidates for this research are healthy adults aged 21 and older who are regular cannabis smokers.

Not a fit: Patients who do not use cannabis or have chronic pain conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved pain management strategies for individuals using cannabis and CBD.

How similar studies have performed: Previous research has shown promising results regarding the analgesic effects of CBD, but this specific approach is relatively novel.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.