Combining two methods for pain relief after knee surgery
Official title: Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty: A Randomized Controlled Trial
Run by Kafrelsheikh University · NCT06837844 · Data updated 2026-11-12
This study is testing if using a combination of a nerve block and a medication can help people feel less pain after knee surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Kafrelsheikh University Academic / other |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Status | Recruiting |
| Started | February 20, 2025 |
| Main results expected | August 1, 2025 |
| Study ends | August 1, 2025 |
| Registry record updated | February 21, 2025 |
| Trial ID | NCT06837844 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 75 scheduled for total knee arthroplasty under spinal anesthesia with ASA physical status I-II.
✕Probably not a fit
Patients with neurological disabilities, allergies to local anesthetics or dexmedetomidine, or those with obesity (BMI > 30 kg/m2) may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of using both intrathecal dexmedetomidine and an adductor canal block for managing pain after total knee arthroplasty. The adductor canal block targets specific nerves to provide localized pain relief, while dexmedetomidine offers additional analgesic and sedative effects. The goal is to enhance postoperative pain management, promote early mobilization, and reduce complications associated with knee surgery.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management for patients undergoing total knee arthroplasty.
How similar studies have gone: While this approach combines established techniques, the specific combination of intrathecal dexmedetomidine and adductor canal block for this purpose is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 75 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status I-II. * Scheduled for total knee arthroplasty under spinal anesthesia. Exclusion Criteria: * Patients with neurological or intellectual disability. * History of allergy to local anesthetics or dexmedetomidine . * Infection at the injection site. * Prolonged use of analgesic or sedative medications. * Coagulation abnormalities. * Pregnancy. * Obesity \[body mass index (BMI) \> 30 kg/m2\].
Where it's running
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Kafrelsheikh University
Kafr ash Shaykh, Kafrelsheikh, Egypt Recruiting
Study contacts
- Study coordinator: Sherif K Arafa, MD
- Email: Sherifhafez1980@gmail.com
- Phone: 00201005714014
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.