Clinical trial Recruiting at 1 site Interventional Ages 18 to 75

Combining two methods for pain relief after knee surgery

Official title: Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty: A Randomized Controlled Trial

Run by Kafrelsheikh University · NCT06837844 · Data updated 2026-11-12

This study is testing if using a combination of a nerve block and a medication can help people feel less pain after knee surgery.

Quick facts

Study typeInterventional
Ages18 Years to 75 Years
SexAll
Enrollment75 (estimated)
SponsorKafrelsheikh University
Academic / other
Locations1 site (Kafr ash Shaykh, Kafrelsheikh)
StatusRecruiting
StartedFebruary 20, 2025
Main results expectedAugust 1, 2025
Study endsAugust 1, 2025
Registry record updatedFebruary 21, 2025
Trial IDNCT06837844 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 75 scheduled for total knee arthroplasty under spinal anesthesia with ASA physical status I-II.

Probably not a fit

Patients with neurological disabilities, allergies to local anesthetics or dexmedetomidine, or those with obesity (BMI > 30 kg/m2) may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of using both intrathecal dexmedetomidine and an adductor canal block for managing pain after total knee arthroplasty. The adductor canal block targets specific nerves to provide localized pain relief, while dexmedetomidine offers additional analgesic and sedative effects. The goal is to enhance postoperative pain management, promote early mobilization, and reduce complications associated with knee surgery.

Why it matters

Potential benefit: If successful, this approach could significantly improve pain management for patients undergoing total knee arthroplasty.

How similar studies have gone: While this approach combines established techniques, the specific combination of intrathecal dexmedetomidine and adductor canal block for this purpose is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age from 18 to 75 years.
* Both sexes.
* American Society of Anesthesiology (ASA) physical status I-II.
* Scheduled for total knee arthroplasty under spinal anesthesia.

Exclusion Criteria:

* Patients with neurological or intellectual disability.
* History of allergy to local anesthetics or dexmedetomidine .
* Infection at the injection site.
* Prolonged use of analgesic or sedative medications.
* Coagulation abnormalities.
* Pregnancy.
* Obesity \[body mass index (BMI) \> 30 kg/m2\].

Where it's running

  • Kafrelsheikh University
    Kafr ash Shaykh, Kafrelsheikh, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.