Clinical trial
Recruiting at 1 site
Interventional
Ages 18 to 45
Women only
Estradiol and Intrusive Memories
Run by Charite University, Berlin, Germany · NCT07419594 · Data updated 2026-11-12
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared wi…
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 273 (estimated) |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Drugs / interventions | Estradiol Valerate, Placebo |
| Locations | 1 site (Germany) |
| Status | Recruiting |
| Started | August 19, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | February 29, 2028 |
| Registry record updated | February 19, 2026 |
| Trial ID | NCT07419594 on ClinicalTrials.gov |
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy female volunteers * German on B1 level Exclusion Criteria: * former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) * any physical illnesses * any medication intake (except oral contraceptive) * history of traumatic experience, e.g. history of sexual abuse or rape * pregnancy or lactation period * intake of oral contraceptives * follicular phase of menstrual cycle
Where it's running
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Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany Recruiting
Study contacts
- Principal investigator: Katja Wingenfeld, Prof. Dr. — Charite University, Berlin, Germany
- Study coordinator: Tolou Maslahati, M.Sc.
- Email: tolou.maslahati@charite.de
- Phone: 0049 30 450 517 567
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team.
Information on this page is for educational purposes and is not medical advice.
Always consult qualified healthcare professionals about clinical trial participation.