Prolonged Exposure Therapy for PTSD in Trauma Patients
Official title: Prevention of Posttraumatic Stress: A Randomized Controlled Trial of Brief Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
Run by Baylor Research Institute · NCT06210711 · Data updated 2026-11-12
This study is testing a short therapy called Brief Prolonged Exposure Therapy to see if it can help trauma patients avoid PTSD and improve their mental health after serious injuries.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Baylor Research Institute Academic / other |
| Locations | 3 sites (Dallas, Texas and 2 other locations) |
| Status | Recruiting |
| Started | February 28, 2024 |
| Main results expected | March 2027 |
| Study ends | September 2027 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT06210711 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 75 who have been admitted to a Level I Trauma Center following a traumatic injury.
✕Probably not a fit
Patients who are in police custody, not fluent in English, have severe cognitive impairment, are acutely suicidal, or have active psychosis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to evaluate the effectiveness of a brief treatment method, specifically Brief Prolonged Exposure Therapy (Brief PE), for preventing posttraumatic stress disorder (PTSD) and other psychological issues following traumatic injuries. The study involves a prospective randomized controlled trial where participants admitted to Level I Trauma Centers will receive either Brief PE or standard clinical care. The intervention consists of three 60-minute sessions aimed at reducing psychological distress and improving long-term health outcomes, including depression and quality of life, assessed at 1, 3, and 6 months post-injury.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce the incidence of PTSD and improve overall mental health outcomes for trauma patients.
How similar studies have gone: Other studies have shown promising results with similar therapeutic approaches, indicating potential for success in this novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Between the ages of 18 and 75 years old. * Admitted to Baylor University Medical Center at Dallas (BUMC), Baylor Scott \& White Medical Center at Temple (BSWMC), or Froedtert Hospital and the Medical College of Wisconsin (FH/MCW) Level 1 Trauma Center Exclusion Criteria: * Patients in police custody * Patients not fluent in English * Patients with severe cognitive impairment * Patients who are acutely suicidal * Patients with active psychosis
Where it's running
-
Baylor University Medical Center
Dallas, Texas, United States Recruiting -
Baylor Scott & White Medical Center - Temple
Temple, Texas, United States Recruiting -
Froedtert & Medical College of Wisconsin
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Ann Marie Warren, PhD — Baylor Scott & White Research Institute
- Study coordinator: Alexis Evans, M.S
- Email: Alexis.Evans@BSWHealth.org
- Phone: (214) 820-9918
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.