Improving PTSD treatment outcomes using adaptive therapy approaches

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to develop a stepped-care model for treating patients with PTSD by comparing the effectiveness of different therapy types. It investigates whether starting with a low- or medium-intensity intervention and adjusting based on patient response leads to better outcomes. The study utilizes prolonged exposure therapy and a mobile app to support treatment. Participants will receive care at federally qualified health centers and will be monitored for symptom reduction over the course of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Receive care at a participating federally qualified health center (FQHC)
* Have a Posttraumatic Stress Disorder checklist (PCL-5) score greater or equal (≥) to 33
* Own a mobile device that can be used for the PTSD Coach App
* Have had psychotropic medication stability for at least 4 weeks

Exclusion Criteria:

* Severe cognitive impairment that in the judgment of the investigators makes it unlikely that the participant can adhere to the study regimen (as evidenced by confusion, inability to track discussion or answer questions, or other clear and significant indicators of cognitive impairment)
* High risk of suicide (defined as meeting criteria for Action Step 3 on the Participant Suicide Risk Screening form
* Severe alcohol or substance use disorder (moderate-severe alcohol use disorder on Alcohol Use Disorders Identification Test (AUDIT) (scores ≥ 15) or high risk on National Institute on Drug Abuse Quick Screen (scores ≥ 27))
* Active psychosis or unmanaged bipolar disorder
* Unstable housing
* Current engagement in a trauma-focused behavioral treatment (such as Prolonged Exposure or Cognitive Processing Therapy).
* Patients who do not speak English will be excluded for logistical reasons.

Where it's running

• Grace Health
  Battle Creek, Michigan, United States Recruiting
• Genesee Community Health Center
  Flint, Michigan, United States Recruiting
• Hamilton Community Health Network
  Flint, Michigan, United States Recruiting
• Cherry Health
  Grand Rapids, Michigan, United States Recruiting
• MidMichigan Community Health Services
  Houghton Lake, Michigan, United States Recruiting
• Upper Great Lakes Family Health Care Center
  Menominee, Michigan, United States Recruiting

Study contacts

• Study coordinator: Kayla Longuski, MS
• Email: kaylsmit@umich.edu
• Phone: 734-647-6258

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.