Condition

Substance Use Disorder (SUD) clinical trials and research

• 32Clinical trials
• 3NIH research projects
• 14Countries

Newest Substance Use Disorder (SUD) clinical trials

All recruiting trials (32)

• Project SHIELD 2.0: Police Education to Support Public Health in Kentucky

  Aimed at police in Kentucky, this program tests whether SHIELD training given to officers, with health workers helping deliver it, can reduce drug-related arrests and steer people who use drugs toward MOUD and other health services.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Lexington, Kentucky · NCT07804121

• Real-time fMRI Neurofeedback for Anhedonia in Methadone-Treated Opioid Use Disorder

  This feasibility study tests a real-time fMRI neurofeedback approach to see if it helps reduce anhedonia in people on methadone for opioid use disorder.

  Recruiting Yale University · New Haven, Connecticut · NCT07768007

• Trauma recovery options for veterans: comparing HRV biofeedback and present-centered therapy

  This trial tests whether Heart Rate Variability Biofeedback plus trauma-informed care helps veterans with PTSD and substance use issues more than present-centered therapy.

  Recruiting Phase 2/3 Coatesville VA Medical Center · Coatesville, Pennsylvania · NCT07756723

• Connecting Loved Ones to Support and Empower Recovery

  A web-based program called KulaMind-Recovery tests whether guided online training, one-on-one coaching, and a community forum help loved ones support someone with a substance use disorder.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07740395

• Next-Generation Dome Helmet for Focused Ultrasound Neuromodulation in Treatment-Resistant Substance Use Disorder

  This study tests whether focused ultrasound delivered through a Dome Helmet can be safely used to target brain regions and help adults with hard-to-treat substance use disorders see if their use declines.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07684976

• NLP-based weekly writings to track mood and worry during residential rehab for SUD

  This study tests whether weekly Spanish narratives and biweekly questionnaires can reveal patterns of mood and thoughts that relate to recovery in adults with substance use disorders in a Mexican rehab center.

  Recruiting Under The Tree Therapeutic Community · Potrerillos, Jalisco · NCT07595614

• Measuring the consequences of substance use

  We will try a new questionnaire to measure treatment outcomes for people affected by substance use disorder, including patients, clinicians, and family members.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT07503067

• Unified care and integrated treatments for ADHD with substance use in prison settings

  Aimed at people under correctional supervision who have ADHD and substance use disorder, this program tests a coordinated care approach to improve identification and support.

  Recruiting University Hospital, Brest · Brest · NCT07487155

• California MEPS Hub for HIV prevention and reentry support

  This project will test a peer-led, app-based program with small cash incentives to help people with substance use recently released from jail or prison get PrEP, HIV/STI testing, and related services.

  Recruiting at 3 sites University of California, Los Angeles · Oakland, California and 2 other locations · NCT07433985

• Person-centered occupational therapy for people with substance use disorder

  This trial will see if an 8-week, person-centered occupational therapy program can help adults with substance use disorder improve daily activities, confidence, and resilience.

  Recruiting Hacettepe University · Istanbul · NCT07364240

• Pilot of two online programs to support people with substance use after release from federal prison

  This project will test two online programs—Breaking Free Online and CBT4CBT—for people recently released from federal custody to help manage substance use and reduce the chance of returning to prison.

  Recruiting at 4 sites St. Joseph's Healthcare Hamilton · Brantford, Ontario and 3 other locations · NCT07342218

• Mild electrical brain stimulation (tDCS) with cognitive training to reduce cocaine cravings.

  This trial will test whether brief sessions of mild electrical brain stimulation (tDCS) combined with cognitive reappraisal training can lower craving in adults receiving inpatient treatment for cocaine use disorder.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07318480

• Reducing Parental Substance Use and Boosting Family Resilience in Rural Ohio

  This study tests whether nearby substance use treatment referrals and family peer mentoring through Ohio START help rural parents reduce substance use and improve child and family wellbeing.

  Recruiting Ohio State University · Columbus, Ohio · NCT07278427

• TBI-RECOVER in Outpatient Substance Use Treatment

  This trial tests whether the TBI-RECOVER program can help people with a substance use disorder who have a brain injury, by improving retention in treatment and managing cognitive and behavioral challenges.

  Recruiting Ohio State University · Columbus, Ohio · NCT07215221

• Personalized adaptive deep brain stimulation for severe opioid use disorder

  This study will test whether personalized deep brain stimulation guided by invasive brain mapping is safe and can reduce cravings and opioid use in adults with severe, treatment-resistant opioid use disorder.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07214467

• Long-acting injectable cabotegravir for preventing HIV in people who inject drugs

  This project tries long-acting injectable cabotegravir plus support services to prevent HIV in adults who inject non-prescription drugs and have sexual exposure risk.

  Recruiting at 2 sites Phase 4 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07199335

• Video support for teens and families after a traumatic injury

  This project tests short video interventions for hospitalized teens and their parents to see if they reduce PTSD symptoms and future substance use after a traumatic injury.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07197476

• Smartphone app training to strengthen inhibition around alcohol or cocaine in teens and young adults

  This project will test a smartphone app that delivers alcohol- or cocaine-specific inhibition training to 14–35-year-olds in treatment for substance use disorder to see if the app is practical to use and affects drinking or drug use.

  Recruiting University of Bern · Bern · NCT07071779

• Peer support in the Vancouver General Hospital emergency department

  This project will try using peer support workers—people with lived experience of substance use—to support adult emergency department patients at Vancouver General Hospital and see if it reduces patients leaving before their care is finished.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07030192

• Comprehensive drug rehabilitation using music therapy

  This trial will test whether adding weekly group active music-making or guided music listening to usual local care helps adults with substance use disorders reduce substance use and improve recovery.

  Recruiting at 7 sites NORCE Norwegian Research Centre AS · Vienna and 10 other locations · NCT07028983

• Optimizing youth mental health trajectories

  This study is trying to understand how mental health changes in young people aged 9 to 25 over five years to see if we can help prevent problems like depression and ADHD.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT06978452

• Using deep brain stimulation to treat severe addiction

  This study is testing if deep brain stimulation can help people with severe addiction who haven't found success with other treatments.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06973512

• Group Cognitive Processing Therapy for people in prison with PTSD and substance use

  This trial tests whether group Cognitive Processing Therapy (CPT) delivered in prison helps adults with PTSD and recent drug problems reduce trauma symptoms, substance use, and re-offending after release.

  Recruiting at 5 sites University of Arkansas · Little Rock, Arkansas and 5 other locations · NCT06923423

• Understanding addiction and trauma among young immigrants in France

  This study looks at how trauma and substance use affect the mental health of young immigrants living in transitional housing in France to help create better support programs for them.

  Recruiting at 7 sites University of Lorraine · Jarville-la-Malgrange and 6 other locations · NCT06922721

• WORTH Paths: digital support for women with substance use and contraception needs

  This study tests whether WORTH Paths, a brief digital group program, can help reproductive-aged women involved in the criminal legal system reduce drug use and increase use of contraception.

  Recruiting Fairleigh Dickinson University · Teaneck, New Jersey · NCT06889831

• A program for transgender adults to support recovery from substance use and HIV risk

  This study is testing a support program for transgender adults to see if it can help them reduce substance use and lower their risk of HIV.

  Recruiting Illinois Institute of Technology · Chicago, Illinois · NCT06880705

• Assessing mental health disorders in Hong Kong using a new recall method

  This study is testing a new way to help people in Hong Kong remember important life events to see how many have experienced major depression and thoughts of suicide.

  Recruiting The University of Hong Kong · Hong Kong · NCT06804525

• Calls and coordination to connect people to care after prison release

  This program will test whether short weekly phone check-ins with a Nurse Case Manager help people leaving prison who have substance use history and chronic medical or psychiatric conditions get more non-emergency outpatient clinic visits.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06794983

• Pathways to equitable perinatal mental health care

  This project will test whether a healthcare-only approach or a healthcare-community partnership helps pregnant and postpartum people get better care for depression and anxiety.

  Recruiting University of Massachusetts, Worcester · Shrewsbury, Massachusetts · NCT06790641

• Mobile smoking cessation program for Veterans undergoing surgery

  This study is testing a mobile program to help Veterans quit smoking before surgery by offering rewards for staying smoke-free.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06678672

• Evaluating pain control methods for postpartum patients with opioid use disorder

  This study tests which pain control method works best for new mothers with opioid use disorder to help them manage pain and improve their overall well-being.

  Recruiting Early Phase 1 Medical College of Wisconsin · Milwaukee, Wisconsin and 1 other locations · NCT06617949

• Psilocybin treatment for individuals with various psychiatric symptoms

  This study is testing if a single dose of psilocybin can help people with different mental health issues like depression, anxiety, and PTSD feel better and improve their daily functioning.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06442423

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Adapting with Proactive SUD Intervention via Disease Intervention Specialists

  A new program uses a proven outreach model to identify and connect people with substance use disorder to care earlier, by applying DIS tactics to SUD in communities.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11422103

• A device to improve sleep for people with substance use disorder

  This study is testing a special headband that uses gentle ultrasound to help people with substance use disorder, especially those struggling with opioid use, get better sleep and feel less anxious about it.

  NIH research Attune Neurosciences, INC. · San Francisco, UNITED STATES · NIH-11069324

• Using long-lasting ketamine to treat substance use disorders without side effects.

  This study is testing a new long-lasting injectable form of ketamine to help people with substance use disorders by reducing cravings and supporting recovery, while aiming to make the treatment easier to stick with and more comfortable.

  NIH research Consegna Pharma, INC. · Pittsburgh, United States · NIH-10744308

Related topics

Quick answers

How many Substance Use Disorder (SUD) clinical trials are recruiting right now?

32, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (20 trials), Canada (5 trials), France (2 trials), Switzerland (2 trials), Austria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Early Phase 1: 1, Phase 1: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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