Condition

Peri-implantitis clinical trials and research

• 33Clinical trials
• 7NIH research projects
• 17Countries

Newest Peri-implantitis clinical trials

All recruiting trials (33)

• How Smoking Affects Immune Responses Around Dental Implants

  This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.

  Recruiting Gazi University · Ankara, Ankara · NCT07750171

• AmbiJet-assisted treatment for inflamed dental implants

  This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.

  Recruiting Freiburger Medizintechnik GmbH · Romny · NCT07722715

• Non-surgical H42 treatment for peri-implant pockets

  This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.

  Recruiting Bioteck S.p.A. · Seville · NCT07680491

• Macrophage behavior around dental implants in health and peri-implantitis

  This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.

  Recruiting Biruni University · Istanbul · NCT07569432

• Access to probing around dental implants

  This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.

  Recruiting at 9 sites Arrow Development · A Coruña, A Coruña and 8 other locations · NCT07557459

• Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement

  This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07550127

• Keratinized mucosa graft to support treatment of peri-implantitis

  This trial will try adding a free gingival graft to non-surgical peri-implantitis care to see if increasing keratinized mucosa helps patients with less than 2 mm of mid‑buccal keratinized tissue heal better.

  Recruiting Gazi University · Ankara · NCT07471386

• Minimally invasive non-surgical treatment for peri-implantitis

  This test compares a gentler, minimally invasive non-surgical cleaning (MINST) with standard non-surgical cleaning for adults who have peri-implantitis to see which gives better gum, bone, and patient-reported outcomes over 12 months.

  Recruiting St. Anne's University Hospital Brno, Czech Republic · Brno · NCT07466966

• Removing the crown during non-surgical treatment for peri-implantitis.

  This study will test whether taking off the prosthetic crown from an affected implant helps non-surgical cleaning work better for people with peri-implantitis.

  Recruiting G. d'Annunzio University · Chieti, Chieti · NCT07391202

• Immediate versus delayed surgical reconstruction for bone defects around dental implants

  This trial will test whether doing bone grafting and membrane placement right away or waiting and doing it after initial healing works better for adults with peri-implantitis-related intra-bony defects around dental implants.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07325747

• Vitamin D and LL-37 Levels in Peri-Implant Fluids

  This study tests whether levels of vitamin D in peri-implant fluids and the antimicrobial peptide LL-37 differ in people with dental implants who have mucositis or peri-implantitis.

  Recruiting Recep Tayyip Erdogan University · Rize, Islampasa Street · NCT07280754

• Antimicrobial photodynamic therapy for non-surgical peri-implantitis care

  This trial will test whether adding antimicrobial photodynamic therapy to standard non-surgical cleaning helps adults with peri-implantitis preserve their implants.

  Recruiting Egas Moniz - Cooperativa de Ensino Superior, CRL · Almada, Monte Da Caparica · NCT07191522

• Natural bioactive gel to treat peri-implantitis around dental implants.

  This study will try adding a natural bioactive gel (Sterify Gel®) to standard non-surgical cleaning to see if adults with peri-implantitis have less inflammation and bone loss around their implants.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07088679

• Immunological and clinical evaluation of the causes of peri-implantitis

  This project will see if blood tests can reveal immune reactions or metal-related signals in adults with advanced peri-implantitis.

  Recruiting Wroclaw Medical University · Wroclaw, Lower Silesian Voivodeship · NCT07012915

• Probing around dental implants before versus after crown removal to detect peri-implantitis

  This test will see if measuring pocket depth and bleeding around dental implants before versus after taking off the crown finds peri-implantitis more accurately in adults with restored implants.

  Recruiting The Dental Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07004517

• Reconstructive treatment for gum disease around dental implants

  This study is testing if adding a special membrane to a bone graft can help people with gum disease around dental implants heal better than just using the bone graft alone.

  Recruiting Gazi University · Ankara, Turkey · NCT06957652

• Using a titanium brush to treat peri-implantitis

  This study is testing if using a titanium brush along with regular cleaning can better treat gum disease around dental implants compared to just using steel tools.

  Recruiting Universitat Internacional de Catalunya · Barcelona, Catalonia · NCT06843928

• Using a chitosan brush to treat peri-implantitis

  This will test whether cleaning infected dental implants with a chitosan brush works better than a titanium curette for adults with peri-implantitis.

  Recruiting Hacettepe University · Ankara · NCT06830200

• Comparing laser and mechanical methods for treating peri-implantitis

  This study is testing three different ways to treat peri-implantitis to see which one helps patients feel better by reducing gum depth around dental implants.

  Recruiting Kırıkkale University · Kirikkale · NCT06685523

• Treatment of peri-implantitis using platelet-rich fibrin

  This study is testing whether adding platelet-rich fibrin to surgery can help people with peri-implantitis heal better and improve bone growth around their dental implants.

  Recruiting University of Bern · Bern · NCT06679283

• Non-surgical treatment for gum disease around dental implants

  This study is testing two different non-surgical treatments for gum disease around dental implants to see which one works better for patients with this condition.

  Recruiting Kutahya Health Sciences University · Kütahya · NCT06514677

• Investigating gene and microbiome profiles in gum diseases

  This study is trying to see how genes and bacteria in the mouth are related to gum diseases like periodontitis and peri-implantitis in adults to help improve diagnosis and treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT06262035

• Using antibacterial photodynamic therapy to treat peri-implantitis

  This study is testing a new light-activated mouth rinse to see if it can help people with peri-implantitis manage their gum inflammation and plaque better.

  Recruiting Koite Health Oy · Stockholm · NCT06017817

• Non-surgical treatment for gum disease's effect on blood vessel health

  This study is testing whether a non-surgical gum treatment can improve blood vessel health in people with gum disease and healthy individuals.

  Recruiting University of Catania · Catania · NCT05906810

• Comparing two surgical methods for treating peri-implantitis

  This study is testing two different surgical methods to see which one works better for treating peri-implantitis in patients with dental implants.

  Recruiting National and Kapodistrian University of Athens · Athens · NCT05899933

• Comparing immediate and delayed loading of zirconia dental implants

  This study tests whether putting zirconia dental implants in right away or waiting a couple of months leads to better success for patients with missing teeth.

  Recruiting Phase 4 University of Milan · Milan · NCT05838365

• Comparing two non-surgical treatments for peri-implantitis

  This study is testing which of two non-surgical treatments for peri-implantitis—mechanical cleaning or air-polishing—works better to improve gum health around dental implants.

  Recruiting Tannhelsetjenestens Kompetansesenter for Nord-Norge · Tromsø, Troms · NCT05683405

• Impact of Implant Shape on Gum Health Around Dental Implants

  This study is testing how different shapes of dental implants affect gum health in patients who have had their implants for over three years.

  Recruiting Universitat Internacional de Catalunya · Sant Cugat del Vallès, Barcelona · NCT05592314

• Comparing soft tissue augmentation methods for treating peri-implantitis

  This study is testing whether using a special collagen matrix or a tissue graft can help people with moderate to severe peri-implantitis heal better when combined with other treatments compared to those who don’t receive any soft tissue help.

  Recruiting University of Zurich · Frankfurt and 2 other locations · NCT05415111

• Evaluating long-term outcomes of surgical treatment for peri-implantitis

  This study looks at how well surgical treatments work for people with peri-implantitis over the long term by checking their healing and collecting samples from new patients for further analysis.

  Recruiting at 3 sites Malmö University · Vienna and 2 other locations · NCT05339789

• Investigating biofilm formation on temporary dental implant components

  This study is testing if a new type of dental implant material can reduce harmful bacteria buildup compared to the standard material to help prevent gum diseases.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT05122897

• Understanding the links between periodontitis, inflammation, and diabetes

  This study is trying to understand how periodontitis and inflammation are connected to diabetes by looking at biological samples from patients with severe gum disease and healthy people.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine and 1 other locations · NCT04831060

• Treatment for peri-implantitis using implantoplasty

  This study tests if adding implantoplasty to standard treatment helps people with peri-implantitis heal better than just the standard treatment alone.

  Recruiting at 2 sites University of Oslo · Oslo, Oslo and 1 other locations · NCT04052373

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how tiny blood vessels behave around dental implants

  A study at Georgetown University looks at why blood vessels near dental implants leak and become inflamed, with the goal of spotting problems early in patients who have implants.

  NIH research Georgetown University · Washington, United States · NIH-11450500

• Understanding and reversing blood vessel problems in peri-implant inflammation

  A study will explore why blood vessels in mouth implants get inflamed and test a drug approach to reverse this process to protect implants.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11351730

• Multi-functional 3D-Printed Dental Implants to Prevent Peri-Implant Infections

  A patient-friendly implant made with a special 3D-printed material that fights infection and helps bone integrate with the implant.

  NIH research Cleveland State University · Cleveland, United States · NIH-11337632

• Bone and soft tissue repair with a piezoelectric hydrogel for peri-implantitis care

  A new gel-like material with piezoelectric properties is being tested to help repair bone and surrounding tissues around dental implants affected by peri-implantitis.

  NIH research Oralbiolife INC · Churchville, United States · NIH-11312068

• Creating advanced dental implants to prevent infections

  This study is testing a new kind of dental implant made just for you that helps prevent infections, using special materials and 3D printing to make it stronger and safer than regular implants.

  NIH research Cleveland State University · Cleveland, United States · NIH-11167708

• Using CCL2 to treat bone loss around dental implants

  This study is looking at a new way to help people with peri-implantitis, a condition that causes inflammation and bone loss around dental implants, by using a special protein to help the body heal and keep the area healthy without needing surgery.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10996384

• How diabetes affects inflammation and infection around dental implants

  This study is looking at how high blood sugar from diabetes might lead to gum problems around dental implants, and it aims to find ways to prevent these issues for people with diabetes by understanding the bacteria in their mouths better.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-10668057

Related topics

Quick answers

How many Peri-implantitis clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in Turkey (Türkiye) (8 trials), Spain (4 trials), Italy (4 trials), Switzerland (3 trials), Sweden (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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