Reconstructive treatment for gum disease around dental implants
Official title: Reconstructive Treatment of Combined Peri-implantitis-related Defects With or Without Collagen Membrane: A Randomized Clinical Study
Run by Gazi University · NCT06957652 · Data updated 2026-11-12
This study is testing if adding a special membrane to a bone graft can help people with gum disease around dental implants heal better than just using the bone graft alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Gazi University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Ankara, Turkey) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | May 4, 2025 |
| Trial ID | NCT06957652 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with peri-implantitis characterized by specific defect configurations and adequate oral hygiene.
✕Probably not a fit
Patients with low plaque and bleeding scores, active periodontal disease, or certain medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical study aims to evaluate the effectiveness of using a resorbable collagen membrane in conjunction with a xenogeneic bone graft for treating peri-implantitis with complex defect configurations. A total of 60 patients will be randomly assigned to receive either the combination treatment or the bone graft alone. The study will assess both clinical outcomes and patient-reported outcomes to determine if the addition of the membrane provides significant benefits over the standard treatment. The focus is on understanding how different defect types may respond to these treatments.
Why it matters
Potential benefit: If successful, this approach could lead to improved treatment outcomes for patients suffering from peri-implantitis.
How similar studies have gone: While some studies have shown mixed results regarding the use of barrier membranes in similar contexts, this specific approach targeting combined defects is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Peri-implantitis defined as the presence of a peri-implant probing pocket depth (PPD) ≥6 mm with bleeding and/or suppuration on probing (BoP/SoP) and radiographic marginal bone loss (MBL) ≥3 mm. * Presence of combined defect configuration Class \[Ib, Ic, Ie with horizontal components (i.e. Class II) (Schwarz et al., 2010)\] with an intrabony compartment of ≥3 mm. * Presence of a minimum width of 2 mm of keratinized peri-implant mucosa on the buccal aspect of the implant. * Implants placed in proper position (inside the bony housing) * Having an implant-supported prosthesis that allows for adequate oral hygiene procedures and peri-implant probing. Exclusion Criteria: * Full-mouth plaque score (FMPS) \< 25% * Full-mouth bleeding score (FMBS) \< 25% * Cigarette smoking \< 10 cig./day, * Diagnosed with active periodontal disease, * Having acute or chronic medical conditions or undergoing medications, such as intravenous amino-bisphosphonates, immunosuppressive drugs, and chemotherapy, that could interfere with the treatment outcome, * Receiving antibiotic treatment in the previous 3 months.
Where it's running
-
Gazi University Faculty of Dentistry
Ankara, Turkey, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Sila Cagri Isler, PhD
- Email: silaisler@gazi.edu.tr
- Phone: +905069966074
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
-
AmbiJet-assisted treatment for inflamed dental implants
This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.
-
Non-surgical H42 treatment for peri-implant pockets
This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.
-
Macrophage behavior around dental implants in health and peri-implantitis
This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
-
Access to probing around dental implants
This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.
-
Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement
This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.