Using a titanium brush to treat peri-implantitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of using a titanium brush in conjunction with non-surgical submucosal debridement for treating peri-implantitis, a condition characterized by inflammation and bone loss around dental implants. The trial aims to compare the clinical, radiographic, and microbiological outcomes of this combined approach against traditional methods using steel curettes alone. Participants will undergo mechanical debridement to remove biofilm and calculus, with the titanium brush potentially enhancing plaque removal. The study will include adult patients with specific criteria related to their dental implants and oral hygiene.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients with ≥18 years of age.
* Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.
* An adequate level of oral hygiene (plaque index ≤ 25%) (O'Leary et al., 1972).
* Treated periodontal disease.
* Presence of at least one titanium implant with peri-implantitis \[i.e., presence of bleeding and/or suppuration on gentle probing with probing depth of ≥6 mm, and progressive bone loss. In the absence of initial radiographs, a bone level ≥2 mm apical to the most coronal part of the intrabony portion of the implant will be used as threshold of disease (Romandini et al., 2021)\].
* Horizontal and vertical peri-implant bone defects.
* Implant function time ≥ 1 year.
* Presence of ≥2mm of keratinized peri-implant mucosa.
* Screw-retained single and multiple restorations.

Exclusion Criteria:

* Untreated periodontitis.
* Smokers \> 10 cigarettes per day.
* Local or systemic diseases that would interfere with routine periodontal therapy (i.e., uncontrolled diabetes mellitus, cancer, HIV, chronic high-dose steroid therapy, metabolic bone disease, radiation, immunosuppressive disease, hepatic dysfunction, immunosuppressive disease, autoimmune disease).
* Pregnant or lactating women.
* Previous surgical and non-surgical treatment of affected implants at least 12 months prior to the beginning of the study.
* Radiographic peri-implant bone loss \> two-thirds.
* Mobility of the implant.
* Known allergy or intolerance to macrolides.
* Use of systemic antibiotics during the last 3 months.
* Need of endocarditis prophylaxis.

Where it's running

• Universitat Internacional de Catalunya
  Barcelona, Catalonia, Spain Recruiting

Study contacts

• Study coordinator: Javi Vilarrasa
• Email: jvilarrasa@uic.es
• Phone: +34 628553000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Non-surgical H42 treatment for peri-implant pockets

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• Macrophage behavior around dental implants in health and peri-implantitis

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• Access to probing around dental implants

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• Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement

  This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07550127

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.