Using a chitosan brush to treat peri-implantitis
Official title: Clinical and Immunological Evaluation of the Efficacy of Chitosan Brush in Non-Surgical Peri-implantitis Treatment
Run by Hacettepe University · NCT06830200 · Data updated 2026-11-12
This will test whether cleaning infected dental implants with a chitosan brush works better than a titanium curette for adults with peri-implantitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Hacettepe University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Ankara) |
| Status | Recruiting |
| Started | April 10, 2025 |
| Main results expected | December 1, 2026 |
| Study ends | June 1, 2027 |
| Registry record updated | September 15, 2025 |
| Trial ID | NCT06830200 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–64 with peri-implantitis on implants placed more than 12 months earlier who can undergo non-surgical debridement and have completed periodontal treatment are ideal candidates.
✕Probably not a fit
Patients needing implant removal, with prosthetic access restrictions, recent systemic antibiotics, current chemo/radiotherapy or long-term steroids, pregnancy/lactation, or ASA score ≥ 3 are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares non-surgical implant debridement using a chitosan brush versus a titanium curette in adults with peri-implantitis. Eligible participants have implants in function for more than 12 months and have completed prior periodontal treatment before enrollment. Treatments are non-surgical and outcomes will include clinical signs of inflammation and measurements of inflammatory cytokines such as IL-1β, IL-6, and TNF-α. The aim is to see if the chitosan brush reduces biofilm and inflammatory markers more effectively than conventional instrumentation.
Why it matters
Potential benefit: If successful, this could offer a less invasive way to reduce implant inflammation and bacterial biofilm, helping preserve implant health and slow bone loss.
How similar studies have gone: Laboratory and small clinical studies show chitosan has antibacterial and anti-inflammatory effects, but strong clinical evidence for non-surgical peri-implantitis treatment is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presence of peri-implantitis in an implant that has been in function for more than 12 months * Age ≥ 18 and \< 65 * Agreeing to participate in the study after reading the informed consent form * Completion of periodontal treatment of patients diagnosed with periodontitis before inclusion in the study Exclusion Criteria: * Patients under 18 years of age * Patients who have received or are currently receiving radiotherapy, chemotherapy and long-term systemic corticosteroid treatment * Patients who received systemic antibiotics within 6 months from baseline * Pregnant or lactating patients * Patients with anatomical abnormalities around the implant (e.g., apically positioned implants adjacent to a tooth) * Patients with prostheses that prevent access for implant debridement with chitosan brushes or titanium curettes * Implants with an overdenture superstructure * Implants to be explanted * Patients with ASA score ≥ 3 * Patients reporting reactions or adverse events to chitosan, stainless steel, adhesives, or polypropylene * Clinically mobile implants * Recently placed and non-osseointegrated implants * Around major nerves and blood vessels, if there is a risk of structural damage
Where it's running
-
Hacettepe University
Ankara, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Buket Acar, PHD
- Email: dtbuketacar@gmail.com
- Phone: +90 312 305 2217
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
-
AmbiJet-assisted treatment for inflamed dental implants
This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.
-
Non-surgical H42 treatment for peri-implant pockets
This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.
-
Macrophage behavior around dental implants in health and peri-implantitis
This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
-
Access to probing around dental implants
This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.
-
Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement
This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.