Comparing laser and mechanical methods for treating peri-implantitis
Official title: Evaluation of Fractalkine and Its Receptor in the Non-Surgical Treatment of Peri-implantitis
Run by Kırıkkale University · NCT06685523 · Data updated 2026-11-12
This study is testing three different ways to treat peri-implantitis to see which one helps patients feel better by reducing gum depth around dental implants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 60 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Kırıkkale University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Kirikkale) |
| Status | Recruiting |
| Started | November 8, 2024 |
| Main results expected | May 8, 2025 |
| Study ends | May 15, 2025 |
| Registry record updated | November 12, 2024 |
| Trial ID | NCT06685523 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 40-60 years with probing depths of 4-6 mm and at least 2 mm of bone loss on X-ray, who have inflammatory symptoms but no systemic diseases affecting treatment outcomes.
✕Probably not a fit
Patients who smoke, drink alcohol, are pregnant or lactating, or have received antibiotic treatment in the last three months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of three different treatment methods for peri-implantitis: mechanical debridement, Er:YAG laser decontamination, and diode laser decontamination. Participants will be assessed based on the reduction of peri-implant sulcus depth following these interventions. The study aims to determine which method provides the best outcomes for patients suffering from this condition. It includes individuals with specific probing depths and bone loss criteria, ensuring a targeted approach to treatment.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment options for patients with peri-implantitis, improving their oral health and implant longevity.
How similar studies have gone: Other studies have shown promising results with laser treatments for peri-implantitis, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Probing depth of 4-6 mm, bone loss of at least 2 mm on X-ray and presence of inflammatory symptoms in soft tissue * No systemic disease that may affect the outcome of the treatment * Patients with healthy periodontium or patients with completed periodontal treatment * Individuals at least 6 months after prosthesis loading on the implant * Individuals who do not require further surgery for the treatment of peri-implantitis * Implants with at least 2 mm keratised gingiva * Individuals aged 40-60 years Exclusion Criteria: * Individuals undergoing radiation therapy * Individuals who smoke and drink alcohol * Individuals in pregnancy or lactation * Individuals who have received antibiotic treatment in the last three months * Individuals with parafunctional habits
Where it's running
-
Kırıkkale University, Faculty of Dentistry, Department of Periodontology
Kirikkale, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Kubilay Barış, Dr.
- Email: kubilaybaris60@hotmail.com
- Phone: +90-0553-973-64-77
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
-
AmbiJet-assisted treatment for inflamed dental implants
This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.
-
Non-surgical H42 treatment for peri-implant pockets
This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.
-
Macrophage behavior around dental implants in health and peri-implantitis
This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
-
Access to probing around dental implants
This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.
-
Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement
This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.