Comparing laser and mechanical methods for treating peri-implantitis

Evaluation of Fractalkine and Its Receptor in the Non-Surgical Treatment of Peri-implantitis

NA · Kırıkkale University · NCT06685523

This study is testing three different ways to treat peri-implantitis to see which one helps patients feel better by reducing gum depth around dental implants.

Quick facts

PhaseNA
Study typeInterventional
Enrollment100 (estimated)
Ages40 Years to 60 Years
SexAll
SponsorKırıkkale University (other)
Drugs / interventionsradiation
Locations1 site (Kirikkale)
Trial IDNCT06685523 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of three different treatment methods for peri-implantitis: mechanical debridement, Er:YAG laser decontamination, and diode laser decontamination. Participants will be assessed based on the reduction of peri-implant sulcus depth following these interventions. The study aims to determine which method provides the best outcomes for patients suffering from this condition. It includes individuals with specific probing depths and bone loss criteria, ensuring a targeted approach to treatment.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 40-60 years with probing depths of 4-6 mm and at least 2 mm of bone loss on X-ray, who have inflammatory symptoms but no systemic diseases affecting treatment outcomes.

Not a fit: Patients who smoke, drink alcohol, are pregnant or lactating, or have received antibiotic treatment in the last three months may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to more effective treatment options for patients with peri-implantitis, improving their oral health and implant longevity.

How similar studies have performed: Other studies have shown promising results with laser treatments for peri-implantitis, suggesting that this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Probing depth of 4-6 mm, bone loss of at least 2 mm on X-ray and presence of inflammatory symptoms in soft tissue
* No systemic disease that may affect the outcome of the treatment
* Patients with healthy periodontium or patients with completed periodontal treatment
* Individuals at least 6 months after prosthesis loading on the implant
* Individuals who do not require further surgery for the treatment of peri-implantitis
* Implants with at least 2 mm keratised gingiva
* Individuals aged 40-60 years

Exclusion Criteria:

* Individuals undergoing radiation therapy
* Individuals who smoke and drink alcohol
* Individuals in pregnancy or lactation
* Individuals who have received antibiotic treatment in the last three months
* Individuals with parafunctional habits

Where this trial is running

Kirikkale

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Peri-implantitis, Er:YAG laser, Debridment, peri-implantitis

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.