Condition

Dental Plaque clinical trials and research

• 16Clinical trials
• 2NIH research projects
• 13Countries

Newest Dental Plaque clinical trials

All recruiting trials (16)

• Toothpaste for reducing dental plaque and preventing gum problems

  This study tests three toothpaste options to see if they reduce plaque and gingivitis in adults with mild gum inflammation.

  Recruiting Phase 3 Colgate Palmolive · Roma, Rome · NCT07842991

• Effect of stannous fluoride toothpaste on gingival health indicators in an experimental gingivitis model

  This study tests whether a toothpaste with stannous fluoride can influence gingival crevicular fluid biomarkers and help gingival tissue recover during early gingivitis.

  Recruiting Haleon · Birmingham · NCT07842042

• Toothpaste that may reduce plaque and gingivitis in Chinese adults

  A toothpaste test will be used to see if it reduces plaque and gingivitis more than a regular fluoride toothpaste in Chinese people with localized gingivitis.

  Recruiting Haleon · Shanghai, Shanghai Municipality · NCT07816406

• Safety and effectiveness of an electric flosser with a manual toothbrush for gingivitis and plaque

  This study tests whether using an electric interproximal flosser in addition to a manual toothbrush can reduce gingival inflammation and plaque in adults with gingivitis compared with brushing alone.

  Recruiting Flaus, Inc · Fort Wayne, Indiana · NCT07779564

• Oil Pulling Mouthwash Reduction in Plaque and Inflammation

  A mouthwash-based study will test whether GuruNanda oil pulling rinse can reduce plaque and gum inflammation and bleeding in healthy adults compared with a competitor mouthwash and a water placebo.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT07706647

• Toothbrushing Education for Kids with Specific Learning Disabilities and Healthy Peers

  This study tests whether a structured toothbrushing education program helps children with specific learning disabilities remove more plaque than healthy peers.

  Recruiting Alanya Alaaddin Keykubat University · Alanya, Antalya · NCT07611942

• Intraoral scanning and CBCT for detecting dental plaque and cavities

  This project tests whether intraoral scans and CBCT can accurately detect dental plaque and cavities in adults aged 18 to 70.

  Recruiting University Hospital, Ghent · Wondelgem, Botestraat · NCT07555223

• Pure green tea mouthwash versus placebo and essential-oil rinses for plaque and gum inflammation

  This trial will see if rinsing twice daily with a pure green tea mouthwash reduces dental plaque and gum inflammation in healthy adults compared with placebo and two commercial mouthwashes.

  Recruiting King Abdullah University Hospital · Irbid, Irbid Governorate · NCT07364565

• Comparing probiotic and ethyl lauroyl arginate mouthwashes for lowering cavity‑causing bacteria and plaque in Egyptian schoolchildren

  This study will test whether a probiotic mouthwash or an ethyl lauroyl arginate mouthwash better lowers Streptococcus mutans, reduces dental plaque, and affects salivary pH in healthy Egyptian children aged 6–12.

  Recruiting Al-Azhar University · Cairo · NCT07356869

• NeoPill to reduce oral bacteria in people with fixed braces

  This trial will see if a single 30-second use of the NeoPill device can quickly lower oral bacterial counts in adults who wear fixed braces.

  Recruiting Neofunction d.o.o. · Limassol · NCT07355400

• Mouth bacteria and artery plaque in people undergoing endarterectomy

  This research will see if the bacteria found in dental plaque are the same as the bacteria found in artery (atheroma) plaque in people having endarterectomy.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul · NCT07100574

• Coenzyme Q10 toothpaste with daily Limosilactobacillus reuteri probiotics to improve gum health during pregnancy

  For pregnant women with gum disease, this will try whether adding a CoQ10 toothpaste and daily L. reuteri probiotic to regular cleanings reduces plaque and gum bleeding.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07029360

• Probiotic treatment for orthodontic patients

  This study is testing if a probiotic lozenge can help reduce dental plaque and cavities in healthy orthodontic patients wearing braces.

  Recruiting University of Aarhus · Aarhus · NCT06751979

• Using antibacterial light therapy to improve oral hygiene in elderly people

  This study tests if using a special blue light device along with regular brushing can help older adults keep their mouths healthier and improve their quality of life.

  Recruiting at 3 sites Koite Health Oy · Loviisa, Uusimaa and 2 other locations · NCT06576063

• Effects of water, stevioside, and sucrose drinks on mouth pH and dental plaque

  This trial tests whether drinking plain water, stevioside‑sweetened, or sugar‑sweetened beverages changes mouth pH and dental plaque bacteria in Mexican adolescents who regularly drink soft drinks.

  Recruiting Phase 1/2 Hospital Infantil de Mexico Federico Gomez · Mexico City, Cuahutemoc · NCT05852145

• Investigating biofilm formation on temporary dental implant components

  This study is testing if a new type of dental implant material can reduce harmful bacteria buildup compared to the standard material to help prevent gum diseases.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT05122897

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Creating a new tool to quickly diagnose oral diseases using dental plaque samples

  This study is testing a new, easy-to-use tool that checks dental plaque for early signs of cavities by measuring certain substances made by mouth bacteria, helping patients quickly understand their oral health and take action to prevent tooth decay.

  NIH research Oregon State University · Corvallis, United States · NIH-11118374

• Understanding how dental plaque affects oral health

  This study is looking at the different types of bacteria in dental plaque and how their arrangement affects your oral health, with the hope of finding out how changes in these bacteria can lead to issues like gum disease and cavities.

  NIH research State University of New York at Albany · Albany, United States · NIH-10929954

Related topics

Quick answers

How many Dental Plaque clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (2 trials), Turkey (Türkiye) (2 trials), Italy (2 trials), Mexico (1 trial), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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