Comparing two surgical methods for treating peri-implantitis
Official title: Implantoplasty Versus Implant Decontamination With Erythritol Air-abrasive Device During Surgical Therapy of Peri-implantitis. Clinical, Radiographic and Microbiological Evaluation. A Randomized Controlled Clinical Study
Run by National and Kapodistrian University of Athens · NCT05899933 · Data updated 2026-11-12
This study is testing two different surgical methods to see which one works better for treating peri-implantitis in patients with dental implants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Athens) |
| Status | Recruiting |
| Started | July 28, 2023 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | April 15, 2026 |
| Trial ID | NCT05899933 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 80 with at least one implant diagnosed with peri-implantitis or healthy implants.
✕Probably not a fit
Patients with implant mobility or those who smoke may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of two different surgical protocols for treating peri-implantitis over a one-year period. It will assess clinical, radiographic, and microbiological outcomes, as well as patient satisfaction following treatment. The study will also compare microbiological results between implants diagnosed with peri-implantitis and healthy implants. Participants will undergo either implantoplasty or treatment with an erythritol air-abrasive device as part of their intervention.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients suffering from peri-implantitis.
How similar studies have gone: Previous studies have shown varying degrees of success with surgical interventions for peri-implantitis, but this specific comparison of methods is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: General Inclusion Criteria: * Participants ≥ 18 years and ≤ 80 years of age * Non-smokers based on the patients' self-reported smoking status, defined as patients who had never smoked or had quit smoking at least 2 years ago * Implants in function for more than 1 year after suprastructure connection Inclusion Criteria for implants diagnosed with Peri-Implantitis: * Presence of at least one implant diagnosed with peri-implantitis defined as presence of bleeding on probing and/or suppuration, probing pocket depth ≥6 mm and ≥3 mm of detectable bone loss after initial re-modelling * Absence of implant mobility * in participants with more than one implant, the implant with the worst clinical condition will be studied. Inclusion Criteria for implants diagnosed with Peri-Implant Health: * Absence of peri-implant signs of inflammation (redness, swelling) * Lack of bleeding on probing * Absence of bone loss beyond crestal bone level changes resulting from initial remodeling, which should not be ≥2 mm Exclusion Criteria: * Smokers * Uncontrolled diabetes mellitus (HBA1c \>7) * Treatment with bisphosphonates * Needing antibiotic prophylaxis * Currently pregnant or breast-feeding women * History of systemic administration of antibiotic treatment during the preceding 3 months * Systemic conditions that contraindicate treatment * Use of medications known to induce gingival hyperplasia
Where it's running
-
Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens
Athens, Greece Recruiting
Study contacts
- Study coordinator: Yiorgos A. Bobetsis, Assistant Professor
- Email: ybobetsi@dent.uoa.gr
- Phone: (+30) 210-746-1097
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
-
AmbiJet-assisted treatment for inflamed dental implants
This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.
-
Non-surgical H42 treatment for peri-implant pockets
This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.
-
Multilayered PRF versus connective tissue graft for anterior implant tissue health
This study tests whether multilayered platelet-rich fibrin can improve soft tissue around front-mouth dental implants as well as the traditional connective tissue graft.
-
Volumetric comparison of soft tissue around PEEK healing abutments vs standard healing abutments for single posterior implants
This study tests whether using a PEEK anatomic healing abutment improves the soft tissue in the area around a single posterior dental implant compared with a standard healing abutment.
-
Macrophage behavior around dental implants in health and peri-implantitis
This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.