Vitamin D and LL-37 Levels in Peri-Implant Fluids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure 25(OH)D3 and LL-37 levels in peri-implant sulcus fluid from adults with dental implants. It aims to describe how these markers relate to peri-implant health status and inflammatory cytokines. No active intervention is planned; data will be analyzed to explore potential associations with implant conditions and local inflammatory processes. The study leverages a single-site setting to collect biological samples and clinical information from eligible participants. Results may inform future research on vitamin D–related pathways in peri-implant disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Being between the ages of 18-65,
* Having dental implants and using implant-supported prostheses for at least one year,
* Not having used systemic and/or topical antibiotics/anti-inflammatory drugs or mouthwashes in the last three months,
* Not having received periodontal/peri-implant treatment in the last six months.

Exclusion Criteria:

* Having a systemic disease or condition that affects peri-implant status,
* Having a metabolic bone disease,
* Bruxism,
* Being pregnant or lactating,
* Having received periodontal/peri-implant treatment within the last 6 months,
* Smoking and alcohol use,
* Taking vitamin D supplements.

Where it's running

• Recep Tayyip Erdoğan University
  Rize, Islampasa Street, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.