How Smoking Affects Immune Responses Around Dental Implants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares smokers and non-smokers who have at least one functioning dental implant and either healthy tissue, peri-implant mucositis, or peri-implantitis. Researchers will collect fluid samples around implants to measure inflammatory and immune-related proteins to understand smoking’s impact on the local response. The goal is to identify biological markers that may help gauge disease risk and severity in the peri-implant space. No interventions are described; the study focuses on observing existing conditions and immune factors. Participants must meet specific criteria and avoid recent periodontal therapies or systemic illnesses that could affect results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* willingness to participate in the study;
* having at least one dental implant that has been in function for at least one year;
* having an implant diagnosed with peri-implant health, peri-implant mucositis, or initial peri-implantitis according to the study definitions; for the initial peri-implantitis group, having an implant with PD of 6-7 mm.

Exclusion Criteria:

* having received periodontal therapy, oral decontamination treatment, antibiotics, or steroids within the last six months before study initiation;
* being pregnant or breastfeeding;
* having rheumatoid arthritis, lupus erythematosus, or poorly controlled systemic diseases such as diabetes or hypertension;
* having a history of radiation therapy or cancer therapy.

Where it's running

• Gazi University
  Ankara, Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Buse Naz Büyükakçalı, DDS — Gazi University
• Study coordinator: Buse Naz Büyükakçalı, DDS
• Email: busenazbuyukakcali@gazi.edu.tr
• Phone: +905448024169

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.