Immunological and clinical evaluation of the causes of peri-implantitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

An international consortium will recruit 100 adults with advanced peri-implantitis (20 per partner site) to collect clinical data and blood samples at five European university centers. Eligible participants must have pocket depths >6 mm, positive bleeding on probing, and bone loss exceeding 66% on at least one implant surface. Collected blood will be analyzed for immunological markers and levels of titanium or other metal ions to compare two leading theories of peri-implantitis origin: bacterial invasion versus an immune reaction to metallic particles. Each partner site will obtain local ethics approval and perform procedures at its clinical facility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* PD (Pocket Depth) at the implant site exceeds 6mm,
* Positive BoP (Bleeding on Probing) index
* Bone loss exceeding 66% on at least one implant surface

Exclusion Criteria:

* General and local contraindications for surgical procedures
* Pregnancy
* Use of bisphosphonates or other antiresorptive medications in medical history

Where it's running

• Oral Surgery Department Wroclaw Medical University
  Wroclaw, Lower Silesian Voivodeship, Poland Recruiting

Study contacts

• Study coordinator: Pawel Kubasiewicz-Ross, PhD, DDS
• Email: pawel.kubasiewicz-ross@umw.edu.pl
• Phone: 504075920

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How Smoking Affects Immune Responses Around Dental Implants

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• AmbiJet-assisted treatment for inflamed dental implants

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• Non-surgical H42 treatment for peri-implant pockets

  This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.

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• Macrophage behavior around dental implants in health and peri-implantitis

  This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.

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• Access to probing around dental implants

  This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.

  Recruiting at 9 sites Arrow Development · A Coruña, A Coruña and 8 other locations · NCT07557459

• Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement

  This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07550127

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.