Treatment of peri-implantitis using platelet-rich fibrin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of platelet-rich fibrin (PRF) in enhancing the surgical treatment of peri-implantitis, a condition characterized by inflammation and bone loss around dental implants. Participants will undergo open flap debridement either with the adjunctive application of PRF or without it, allowing for a comparison of outcomes. The study aims to assess improvements in bone regeneration and healing in patients with peri-implantitis defects. By evaluating the impact of PRF on treatment outcomes, the research seeks to provide evidence for its use in clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. One or more peri-implant sites with PPD ≧ 5 mm combined with BOP/suppuration and
2. Peri-implant marginal bone loss, defined as a crater like defect ≧ 3 mm as assessed from intraoral radiographs
3. Good oral hygiene i.e. a plaque index \<20%
4. Written informed consent

Exclusion Criteria:

1. History of chronic inflammatory disease
2. Severe systemic diseases
3. Medically confirmed diagnosis of diabetes mellitus
4. Anti-inflammatory prescription including prednisone
5. Smoking \> 5 cigarettes
6. Pregnant or lactating women
7. \< 18 years of age

Where it's running

• Department of Periodontology, University of Bern
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Giovanni Salvi, MD — University of Bern
• Study coordinator: Alexandra Stähli, MD
• Email: alexandra.staehli@unibe.ch
• Phone: +41316840727

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.