Using CCL2 to treat bone loss around dental implants
Local Delivery of CCL2 to Reverse Peri-implant Bone Loss in Murine Peri-implantitis
This study is looking at a new way to help people with peri-implantitis, a condition that causes inflammation and bone loss around dental implants, by using a special protein to help the body heal and keep the area healthy without needing surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10996384 on NIH RePORTER |
What this research studies
This research investigates a new approach to treat peri-implantitis, an inflammatory disease affecting dental implants, which leads to bone loss. The study focuses on the local delivery of a protein called CCL2 to help modulate the immune response and restore balance between the host and the microbiome. By using a mouse model, researchers will explore how CCL2 can promote healing and prevent further tissue destruction around dental implants. This innovative method aims to reduce the need for invasive surgical treatments currently used for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received dental implants and are experiencing or at risk of peri-implantitis.
Not a fit: Patients who do not have dental implants or those with other unrelated dental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a less invasive treatment option for patients suffering from peri-implantitis, potentially preserving dental implants and improving oral health.
How similar studies have performed: Previous studies have shown promise in using immunomodulatory strategies for treating inflammatory diseases, suggesting potential success for this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Cho, Yejin — University of Pittsburgh at Pittsburgh
- Study coordinator: Cho, Yejin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.