Using CCL2 to treat bone loss around dental implants
Official title: Local Delivery of CCL2 to Reverse Peri-implant Bone Loss in Murine Peri-implantitis
Funded at University of Pittsburgh at Pittsburgh · NIH-10996384 · Data updated 2026-11-12
This study is looking at a new way to help people with peri-implantitis, a condition that causes inflammation and bone loss around dental implants, by using a special protein to help the body heal and keep the area healthy without needing surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $54,774 |
| NIH project number | 1F30DE033606-01A1 |
| Project ID | NIH-10996384 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received dental implants and are experiencing or at risk of peri-implantitis.
✕Less likely to help
Patients who do not have dental implants or those with other unrelated dental conditions may not benefit from this research.
What this research studies
This research investigates a new approach to treat peri-implantitis, an inflammatory disease affecting dental implants, which leads to bone loss. The study focuses on the local delivery of a protein called CCL2 to help modulate the immune response and restore balance between the host and the microbiome. By using a mouse model, researchers will explore how CCL2 can promote healing and prevent further tissue destruction around dental implants. This innovative method aims to reduce the need for invasive surgical treatments currently used for this condition.
Why it matters
Potential benefit: If successful, this research could provide a less invasive treatment option for patients suffering from peri-implantitis, potentially preserving dental implants and improving oral health.
How similar studies have gone: Previous studies have shown promise in using immunomodulatory strategies for treating inflammatory diseases, suggesting potential success for this novel approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Cho, Yejin — University of Pittsburgh at Pittsburgh
- Study coordinator: Cho, Yejin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.