Macrophage behavior around dental implants in health and peri-implantitis
Official title: Investigation of Macrophage Polarization in Peri-implant Health and Peri-implantitis
Run by Biruni University · NCT07569432 · Data updated 2026-11-12
This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Biruni University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | December 31, 2025 |
| Main results expected | December 2027 |
| Study ends | September 2028 |
| Registry record updated | October 1, 2026 |
| Trial ID | NCT07569432 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with at least one bone-level dental implant who meet the 2017 peri-implant disease criteria and are scheduled for exposure surgery are ideal candidates.
✕Probably not a fit
Patients with prior peri-implant surgery, uncontrolled systemic disease, recent antibiotic or anti-inflammatory use, pregnancy or contraindications to dental surgery are unlikely to be eligible or to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study that will collect peri-implant tissue and fluid samples from adults with and without peri-implantitis who are scheduled for implant exposure surgery. Laboratory measurements will include markers related to macrophage polarization (for example, soluble CD163, BAFF and related cytokines) and characterization of pro-inflammatory (M1) versus anti-inflammatory (M2) profiles. The study will compare marker levels between peri-implantitis cases and controls and perform subgroup analyses by smoking status. Results aim to clarify immune patterns at failing implants that might inform future diagnostics or targeted therapies.
Why it matters
Potential benefit: If successful, this could identify immune markers that help guide earlier or more targeted treatments to preserve dental implants.
How similar studies have gone: Prior studies suggest smoking alters macrophage polarization and that markers like sCD163 and BAFF relate to periodontal inflammation, but data specifically linking these markers to peri-implantitis are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who is suitable for the peri-implantitis diagnosis according to the classifications of periodontal and peri-implant diseases and conditions established in 2017. * Individuals with at least one bone-level dental implant and scheduled to undergo exposure surgery. Exclusion Criteria: * prior peri-implantitis surgery * being diagnosed with autoimmune disease, genetic disorders, bone metabolism disorders, poorly controlled systemic diseases (such as diabetes or hypertension) * pregnancy or lactation * having a history of oral malignancy, chemotherapy or radiotherapy * use of anti-inflammatory drugs within 2 weeks, antibiotics within 3 months, * need for prophylactic antibiotics * contraindications for dental/surgical procedures.
Where it's running
-
Biruni University
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Ayse Kaban — Biruni University
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.