Investigating biofilm formation on temporary dental implant components
Official title: Temporary push-on Rings of Antimicrobial Alloys for Transmucosal Implant Abutment Systems: a Randomized Clinical Study on Early and Mature Biofilm Formation
Run by University Hospital, Basel, Switzerland · NCT05122897 · Data updated 2026-11-12
This study is testing if a new type of dental implant material can reduce harmful bacteria buildup compared to the standard material to help prevent gum diseases.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 33 (estimated) |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel) |
| Status | Recruiting |
| Started | January 11, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 11, 2026 |
| Trial ID | NCT05122897 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with one or more bone-level titanium implants who are not experiencing systemic illness or active periodontitis.
✕Probably not a fit
Patients with systemic illnesses, heavy smokers, or those with active periodontitis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the formation and composition of oral biofilm on temporary push-on cones made from a noble-alloy material compared to a titanium alloy used in dental implants. It evaluates biofilm development at three time points: early (48 hours), mature (2 weeks), and long-term (3 months). The goal is to determine if the new material can reduce bacterial colonization and the risk of peri-implant diseases compared to the current standard. Participants will be monitored for biofilm accumulation and related outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved dental implant materials that reduce the risk of peri-implantitis and enhance oral health.
How similar studies have gone: Other studies have shown promising results with similar approaches in reducing biofilm accumulation on dental materials, suggesting potential for success in this investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed Consent signed by the subject * Presence of one or more bone level titanium implant prior to insertion of the final restoration * No systemic illness * No heavy smoking (smoking \<10 cigarettes/day) * No pregnancy * No active periodontitis (probing pocket depth ≤4 mm) * No pharmacological treatment or antibiotic therapy during or up to three months before the study Exclusion Criteria: * Systemic illness (e.g. Diabetes) * Heavy smoking (smoking \>10 cigarettes/day) * Known or suspected non-compliance, drug or alcohol abuse * Pregnancy * Active periodontitis (probing pocket depth \>4 mm) * Pharmacological treatment or antibiotic therapy during or up to three months before the study
Where it's running
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UZB (University Center for Dental Medicine Basel)
Basel, Switzerland Recruiting
Study contacts
- Principal investigator: Nicola U. Zitzmann, Prof. Dr. — University Center for Dental Medicine Basel
- Study coordinator: Nicola U. Zitzmann, Prof. Dr.
- Email: n.zitzmann@unibas.ch
- Phone: +41 61 267 26 36
Similar studies
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This study tests whether using an electric interproximal flosser in addition to a manual toothbrush can reduce gingival inflammation and plaque in adults with gingivitis compared with brushing alone.
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How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.