Antimicrobial photodynamic therapy for non-surgical peri-implantitis care

Efficacy of Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implantitis

This trial will test whether adding antimicrobial photodynamic therapy to standard non-surgical cleaning helps adults with peri-implantitis preserve their implants.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Egas Moniz - Cooperativa de Ensino Superior, CRL (Academic / other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Almada, Monte Da Caparica)
• Trial ID: NCT07191522 on ClinicalTrials.gov

What this trial studies

Investigators will first perform an epidemiological assessment of factors associated with peri-implantitis in Portugal and then enroll eligible adult patients with peri-implantitis. Participants will receive mechanical debridement with titanium curettes and ultrasonic instruments either alone or combined with antimicrobial photodynamic therapy (aPDT). Clinical outcomes such as implant stability, local infection, bone loss, and gingival indices will be followed over time to compare the two approaches. Standard exclusion criteria (for example, smoking, uncontrolled periodontitis, certain systemic diseases, recent antibiotics/NSAIDs/immunosuppressants, cemented crowns that prevent access, pregnancy, recent cancer therapy, or prior surgery at the same site) are applied.

Who should consider this trial

Good fit: Adults (≥18) with one or more dental implants rehabilitated for at least one year and diagnosed with peri-implantitis, with good local periodontal indices (PI and GI <25%), who are non-smokers and have no excluded systemic conditions or recent interfering medications.

Not a fit: Smokers, people with uncontrolled periodontitis or systemic conditions like diabetes, those with cemented restorations that prevent access, recent users of antibiotics/NSAIDs/immunosuppressants, pregnant or lactating women, recent chemo/radiotherapy recipients, those with prior surgery at the same site, or uncooperative patients are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, adding aPDT could reduce infection and bone loss around implants, helping patients avoid further surgery or implant loss.

How similar studies have performed: Previous trials of aPDT as an adjunct to mechanical debridement for peri-implantitis have shown mixed, modest results and no definitive consensus.

Eligibility criteria

Inclusion Criteria:

* patients over 18 years of age;
* patients with one or more implants diagnosed with peri-implantitis rehabilitated for at least one year;
* PI and GI \< 25%.

Exclusion Criteria:

* smoking patients;
* patients with uncontrolled periodontitis;
* systemic diseases that influence the study (diabetes);
* inadequate prosthetic rehabilitation that cannot be modified or that prevents access for physical decontamination;
* implants rehabilitated with cemented crowns;
* pregnant and lactating women;
* previous surgical intervention at the same site;
* therapy with non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics or immunosuppressants in the last 3 months;
* patients previously undergoing chemotherapy or radiotherapy;
* PI and IG \> 25%;
* uncooperative patients.

Where this trial is running

Almada, Monte Da Caparica

• Egas Moniz School of Health and Science — Almada, Monte Da Caparica, Portugal (Recruiting)

Study contacts

• Principal investigator: Ricardo Alves, PhD — Egas Moniz School of Health and Science
• Study coordinator: Mariana A Assunção, Master

Conditions Peri Implantitis; Peri-implantitis; Antimicrobial Photodynamic Therapy