Antimicrobial photodynamic therapy for non-surgical peri-implantitis care
Official title: Efficacy of Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implantitis
Run by Egas Moniz - Cooperativa de Ensino Superior, CRL · NCT07191522 · Data updated 2026-11-12
This trial will test whether adding antimicrobial photodynamic therapy to standard non-surgical cleaning helps adults with peri-implantitis preserve their implants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Egas Moniz - Cooperativa de Ensino Superior, CRL Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Almada, Monte Da Caparica) |
| Status | Recruiting |
| Started | May 14, 2025 |
| Main results expected | July 30, 2026 |
| Study ends | July 30, 2027 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07191522 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with one or more dental implants rehabilitated for at least one year and diagnosed with peri-implantitis, with good local periodontal indices (PI and GI <25%), who are non-smokers and have no excluded systemic conditions or recent interfering medications.
✕Probably not a fit
Smokers, people with uncontrolled periodontitis or systemic conditions like diabetes, those with cemented restorations that prevent access, recent users of antibiotics/NSAIDs/immunosuppressants, pregnant or lactating women, recent chemo/radiotherapy recipients, those with prior surgery at the same site, or uncooperative patients are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Investigators will first perform an epidemiological assessment of factors associated with peri-implantitis in Portugal and then enroll eligible adult patients with peri-implantitis. Participants will receive mechanical debridement with titanium curettes and ultrasonic instruments either alone or combined with antimicrobial photodynamic therapy (aPDT). Clinical outcomes such as implant stability, local infection, bone loss, and gingival indices will be followed over time to compare the two approaches. Standard exclusion criteria (for example, smoking, uncontrolled periodontitis, certain systemic diseases, recent antibiotics/NSAIDs/immunosuppressants, cemented crowns that prevent access, pregnancy, recent cancer therapy, or prior surgery at the same site) are applied.
Why it matters
Potential benefit: If successful, adding aPDT could reduce infection and bone loss around implants, helping patients avoid further surgery or implant loss.
How similar studies have gone: Previous trials of aPDT as an adjunct to mechanical debridement for peri-implantitis have shown mixed, modest results and no definitive consensus.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients over 18 years of age; * patients with one or more implants diagnosed with peri-implantitis rehabilitated for at least one year; * PI and GI \< 25%. Exclusion Criteria: * smoking patients; * patients with uncontrolled periodontitis; * systemic diseases that influence the study (diabetes); * inadequate prosthetic rehabilitation that cannot be modified or that prevents access for physical decontamination; * implants rehabilitated with cemented crowns; * pregnant and lactating women; * previous surgical intervention at the same site; * therapy with non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics or immunosuppressants in the last 3 months; * patients previously undergoing chemotherapy or radiotherapy; * PI and IG \> 25%; * uncooperative patients.
Where it's running
-
Egas Moniz School of Health and Science
Almada, Monte Da Caparica, Portugal Recruiting
Study contacts
- Principal investigator: Ricardo Alves, PhD — Egas Moniz School of Health and Science
- Study coordinator: Mariana A Assunção, Master
- Email: massuncao@egasmoniz.edu.pt
- Phone: +351919970304
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
-
AmbiJet-assisted treatment for inflamed dental implants
This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.
-
Non-surgical H42 treatment for peri-implant pockets
This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.
-
Macrophage behavior around dental implants in health and peri-implantitis
This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
-
Access to probing around dental implants
This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.
-
Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement
This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.