Comparing immediate and delayed loading of zirconia dental implants
Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial
This study tests whether putting zirconia dental implants in right away or waiting a couple of months leads to better success for patients with missing teeth.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 220 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Milan Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan) |
| Trial ID | NCT05838365 on ClinicalTrials.gov |
What this trial studies
This study investigates the success rate of zirconia dental implants loaded immediately within 7 days versus those loaded after 8 weeks. It focuses on patients with partial edentulism and evaluates various clinical and biological parameters over a 5-year period. The study aims to determine the effectiveness of each loading approach in terms of implant success and patient outcomes, using standardized criteria and patient-reported measures.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy individuals with partial edentulism in premolar or molar positions who meet specific bone and tissue criteria.
Not a fit: Patients with serious health conditions, heavy smokers, or those with untreated periodontal disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into optimal loading times for dental implants, potentially improving patient outcomes and satisfaction.
How similar studies have performed: Previous studies have shown varying success rates with different loading protocols for dental implants, making this investigation relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sistemically healthy patients * partial edentulism * premolar position * molar position * Bone width and height at least 6 and 10mm, respectively. * Keratinized tissue, at least 1 mm at implant site * Full understanding of the proposed surgical treatments and the protocol schedule * Full comprehension and availability to sign the informed consent form Exclusion Criteria: * Heavy smokers (\>10 cigarettes a day) * Serious kidney or liver diseases * Uncontrolled diabetes * Bisphosphonates intake * History of radiotherapy of the head and neck * Current antiblastic chemotherapy * Congenital (primary) or acquired (secondary) immunodeficiency * Pregnant women * Connective tissue disorders Local exclusion criteria: * untreated stage III/IV periodontitis * Autoimmune diseases * oral parafunctions
Where this trial is running
Milan
- San Paolo Hospital — Milan, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.