Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 to 80

Comparing immediate and delayed loading of zirconia dental implants

Official title: Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial

Run by University of Milan · NCT05838365 · Data updated 2026-11-12

This study tests whether putting zirconia dental implants in right away or waiting a couple of months leads to better success for patients with missing teeth.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment220 (estimated)
SponsorUniversity of Milan
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Milan)
StatusRecruiting
StartedDecember 1, 2022
Main results expectedJune 1, 2024
Study endsJune 1, 2029
Registry record updatedMay 1, 2023
Trial IDNCT05838365 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are systemically healthy individuals with partial edentulism in premolar or molar positions who meet specific bone and tissue criteria.

Probably not a fit

Patients with serious health conditions, heavy smokers, or those with untreated periodontal disease may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the success rate of zirconia dental implants loaded immediately within 7 days versus those loaded after 8 weeks. It focuses on patients with partial edentulism and evaluates various clinical and biological parameters over a 5-year period. The study aims to determine the effectiveness of each loading approach in terms of implant success and patient outcomes, using standardized criteria and patient-reported measures.

Why it matters

Potential benefit: If successful, this study could provide insights into optimal loading times for dental implants, potentially improving patient outcomes and satisfaction.

How similar studies have gone: Previous studies have shown varying success rates with different loading protocols for dental implants, making this investigation relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Sistemically healthy patients
* partial edentulism
* premolar position
* molar position
* Bone width and height at least 6 and 10mm, respectively.
* Keratinized tissue, at least 1 mm at implant site
* Full understanding of the proposed surgical treatments and the protocol schedule
* Full comprehension and availability to sign the informed consent form

Exclusion Criteria:

* Heavy smokers (\>10 cigarettes a day)
* Serious kidney or liver diseases
* Uncontrolled diabetes
* Bisphosphonates intake
* History of radiotherapy of the head and neck
* Current antiblastic chemotherapy
* Congenital (primary) or acquired (secondary) immunodeficiency
* Pregnant women
* Connective tissue disorders

Local exclusion criteria:

* untreated stage III/IV periodontitis
* Autoimmune diseases
* oral parafunctions

Where it's running

  • San Paolo Hospital
    Milan, Italy
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.