Comparing immediate and delayed loading of zirconia dental implants
Official title: Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial
Run by University of Milan · NCT05838365 · Data updated 2026-11-12
This study tests whether putting zirconia dental implants in right away or waiting a couple of months leads to better success for patients with missing teeth.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | University of Milan Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | December 1, 2022 |
| Main results expected | June 1, 2024 |
| Study ends | June 1, 2029 |
| Registry record updated | May 1, 2023 |
| Trial ID | NCT05838365 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are systemically healthy individuals with partial edentulism in premolar or molar positions who meet specific bone and tissue criteria.
✕Probably not a fit
Patients with serious health conditions, heavy smokers, or those with untreated periodontal disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the success rate of zirconia dental implants loaded immediately within 7 days versus those loaded after 8 weeks. It focuses on patients with partial edentulism and evaluates various clinical and biological parameters over a 5-year period. The study aims to determine the effectiveness of each loading approach in terms of implant success and patient outcomes, using standardized criteria and patient-reported measures.
Why it matters
Potential benefit: If successful, this study could provide insights into optimal loading times for dental implants, potentially improving patient outcomes and satisfaction.
How similar studies have gone: Previous studies have shown varying success rates with different loading protocols for dental implants, making this investigation relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sistemically healthy patients * partial edentulism * premolar position * molar position * Bone width and height at least 6 and 10mm, respectively. * Keratinized tissue, at least 1 mm at implant site * Full understanding of the proposed surgical treatments and the protocol schedule * Full comprehension and availability to sign the informed consent form Exclusion Criteria: * Heavy smokers (\>10 cigarettes a day) * Serious kidney or liver diseases * Uncontrolled diabetes * Bisphosphonates intake * History of radiotherapy of the head and neck * Current antiblastic chemotherapy * Congenital (primary) or acquired (secondary) immunodeficiency * Pregnant women * Connective tissue disorders Local exclusion criteria: * untreated stage III/IV periodontitis * Autoimmune diseases * oral parafunctions
Where it's running
-
San Paolo Hospital
Milan, Italy Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How Smoking Affects Immune Responses Around Dental Implants
This study tests how smoking changes the body's immune response around dental implants in people with healthy implants, peri-implant mucositis, or peri-implantitis.
-
AmbiJet-assisted treatment for inflamed dental implants
This study tests whether applying cold atmospheric plasma with the AmbiJet system after standard cleaning helps reduce inflammation around dental implants more quickly in adults with peri-implant mucositis or peri-implantitis.
-
Vitamin D and LL-37 Levels in Peri-Implant Fluids
This study tests whether levels of vitamin D in peri-implant fluids and the antimicrobial peptide LL-37 differ in people with dental implants who have mucositis or peri-implantitis.
-
Non-surgical treatment for gum disease's effect on blood vessel health
This study is testing whether a non-surgical gum treatment can improve blood vessel health in people with gum disease and healthy individuals.
-
Treatment for peri-implantitis using implantoplasty
This study tests if adding implantoplasty to standard treatment helps people with peri-implantitis heal better than just the standard treatment alone.
-
Home-use dual-light antibacterial therapy for peri-implant mucositis around full-arch implants
This study tests whether a home-use dual-light device added to standard care can better control gum inflammation around full-arch dental implants than standard care alone.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.