Using antibacterial photodynamic therapy to treat peri-implantitis
Official title: Regular Home-use of Antibacterial Photodynamic Therapy in the Management of Peri-implantitis
Run by Koite Health Oy · NCT06017817 · Data updated 2026-11-12
This study is testing a new light-activated mouth rinse to see if it can help people with peri-implantitis manage their gum inflammation and plaque better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Koite Health Oy Industry-sponsored |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | May 13, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 7, 2026 |
| Trial ID | NCT06017817 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with probing pocket depth of 6 mm or greater and marginal bone loss exceeding 3 mm around dental implants.
✕Probably not a fit
Patients with systemic diseases affecting wound healing, active smokers, or those who have undergone recent periodontal treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of the Lumoral method, which utilizes antibacterial photodynamic therapy (aPDT) to manage peri-implantitis. The approach involves using a photoactive mouth rinse that adheres to dental plaque and is activated by a light applicator, aiming to improve plaque control and reduce inflammation. Participants will receive standard oral hygiene instructions alongside the Lumoral treatment, and their progress will be monitored through clinical assessments of inflammation and plaque levels. The study seeks to determine if this innovative method can enhance long-term outcomes for patients with peri-implantitis.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective and less invasive option for managing peri-implantitis, improving oral health and implant longevity.
How similar studies have gone: Preliminary results from similar approaches using antibacterial photodynamic therapy have shown promising outcomes, suggesting potential for success in this study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * PPD ≥6 mm and marginal bone loss \>3 mm * Dental implants collected and clinically characterized according to Lähteenmäki et al. CEDR-22 * Agreement to participate in the study and to sign a written consent form * Able to co-operate with the treatment protocol and avoid any other oral hygiene measures outside of the study protocol Exclusion Criteria: * Presence of any physical limitation or restriction that might restrict Lumoral use * Unwilling to participate in the study * Pregnancy or lactation * Active smoking * Medicated diabetes mellitus (DM) * Any systemic disease (e.g., wound healing dysfunctions) that could alter the progression of peri-implantitis * Use of antibiotics and doxycycline, chlorhexidine, and bisphosphonates, within 4 weeks week prior to study participation * Peri-implant and periodontal treatment within 3 months prior to study participation * Removable major prosthesis or major orthodontic appliance
Where it's running
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Södertandläkarna AB
Stockholm, Sweden Recruiting
Study contacts
- Principal investigator: Nilminie Rathnayake, Assoc Prof — University of Helsinki
- Study coordinator: Mikko Kylmänen
- Email: mikko.kylmanen@koitehealth.com
- Phone: +358407245934
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests whether H42 can help heal peri-implant pockets compared with no-H42 care in adults with 6–8 mm pockets.
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This study will test whether macrophage-related markers in tissue and fluids around dental implants differ between people with peri-implantitis and those with healthy implants, and whether smoking changes those markers.
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This multicenter study tests whether limited access to peri-implant probing is linked to more bone loss around dental implants in adults with implants in use for at least three years.
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Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement
This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.