Natural bioactive gel to treat peri-implantitis around dental implants.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, controlled, split-mouth clinical trial in which each participant serves as their own control: one affected implant will receive standard non-surgical therapy plus a mucoadhesive bioactive gel (Sterify Gel®) and a second implant will receive standard therapy alone. The gel contains polyvinyl polymers, hydroxytyrosol, magnesium ascorbyl phosphate, and the antimicrobial peptide nisin and is applied as an adjunct to mechanical debridement and air-polishing. Twenty patients with at least two implants in different quadrants affected by peri-implantitis will be enrolled and followed for nine months. Clinical outcomes will include plaque levels, bleeding on probing, probing depth, and radiographic measures of bone loss.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 70 years
* Presence of peri-implantitis involving at least two dental implants located in different quadrants
* Presence of bleeding and/or suppuration on probing
* Increased probing depth (PD) and radiographic bone loss compared to previous examinations
* In the absence of previous clinical data: PD ≥ 6 mm and bone loss ≥ 3 mm apically from the coronal portion of the intraosseous implant area (radiographically assessed)
* Willingness and ability to comply with study protocol and follow-up visits
* Written informed consent provided

Exclusion Criteria:

* Patients with cardiac pacemakers or other implanted electronic devices
* Neurological or psychiatric disorders that may interfere with study participation
* Systemic diseases, metabolic disorders, or autoimmune conditions
* Pregnancy or lactation Current participation in other clinical trials

Where it's running

• Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
  Pavia, Lombardy, Italy Recruiting

Study contacts

• Principal investigator: Andrea Scribante, Associate Professor — University of Pavia
• Study coordinator: Andrea Scribante, Associate Professor
• Email: andrea.scribante@unipv.it
• Phone: +39 0382516223

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• AmbiJet-assisted treatment for inflamed dental implants

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.