How diabetes affects inflammation and infection around dental implants
Official title: Impact of Diabetes hyperglycemia on peri-implantitis
Funded at Nova Southeastern University · NIH-10668057 · Data updated 2026-11-12
This study is looking at how high blood sugar from diabetes might lead to gum problems around dental implants, and it aims to find ways to prevent these issues for people with diabetes by understanding the bacteria in their mouths better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $434,746 |
| NIH project number | 1R21DE032156-01A1 |
| Project ID | NIH-10668057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with diabetes who have received or are considering dental implants.
✕Less likely to help
Patients without diabetes or those who have not undergone dental implant procedures may not benefit from this research.
What this research studies
This research investigates the relationship between diabetes-related high blood sugar levels and the development of peri-implantitis, a condition that causes inflammation and bone loss around dental implants. The study aims to understand how hyperglycemia alters the oral microbiome and contributes to inflammation, using advanced techniques like 16S rRNA sequencing to analyze microbial communities. By examining these mechanisms, the research seeks to identify potential interventions that could help prevent peri-implantitis in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for peri-implantitis in patients with diabetes, enhancing their oral health and quality of life.
How similar studies have gone: Previous studies have indicated a link between diabetes and peri-implantitis, suggesting that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
-
Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Han, Xiaozhe — Nova Southeastern University
- Study coordinator: Han, Xiaozhe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.