Understanding how certain enzymes affect fat breakdown and metabolic diseases
Official title: Defining the roles of ACAD10/11 in hydroxy lipid catabolism and metabolic disease
Funded at Washington University · NIH-11094748 · Data updated 2026-11-12
This study is looking at how certain enzymes help break down a type of fatty acid that could be important for people with obesity and type 2 diabetes, to see how they might affect energy production in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $406,853 |
| NIH project number | 5R01DK137976-02 |
| Project ID | NIH-11094748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from obesity, insulin resistance, type 2 diabetes, or related metabolic disorders.
✕Less likely to help
Patients with metabolic conditions not related to fatty acid metabolism may not benefit from this research.
What this research studies
This research investigates the roles of specific enzymes, ACAD10 and ACAD11, in the breakdown of fatty acids, particularly focusing on a type of fatty acid known as 4-hydroxy fatty acids. By exploring how these enzymes convert 4-hydroxy fatty acids into forms that can be utilized for energy production, the research aims to uncover their significance in metabolic diseases such as obesity and type 2 diabetes. The approach involves advanced techniques like mass spectrometry to analyze lipid profiles in human plasma and understand the physiological implications of these fatty acids.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for metabolic diseases linked to fatty acid metabolism.
How similar studies have gone: Previous research has shown promising results in understanding fatty acid metabolism, but the specific roles of ACAD10 and ACAD11 in this context are novel and largely unexplored.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Pagliarini, David J — Washington University
- Study coordinator: Pagliarini, David J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.