Understanding how environmental factors affect human health
Official title: Natural History of The Human Biological Response to Environmental Exposure and Injury
Run by National Institutes of Health Clinical Center (CC) · NCT04888923 · Data updated 2026-11-12
This study looks at how things like pollution and diet affect our health, especially inflammation and metabolic diseases, by collecting samples and health information from participants.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Research Triangle Park, North Carolina) |
| Status | Recruiting |
| Started | November 16, 2021 |
| Main results expected | December 31, 2031 |
| Study ends | December 31, 2031 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT04888923 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults aged 18 and older who can provide informed consent and are willing to participate in all study procedures.
✕Probably not a fit
Patients who are currently pregnant, lactating, or have conditions that may pose undue risk during study procedures will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between environmental exposures, such as pollution and diet, and their impact on human health, particularly focusing on inflammation and metabolic diseases. Participants will provide various biological samples, including blood, urine, and saliva, and answer health-related questionnaires to help researchers identify how these factors contribute to disease development. The study will analyze biological markers of injury and inflammation to better understand the mechanisms behind environmentally induced health issues.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for diseases linked to environmental factors.
How similar studies have gone: Other studies have shown success in understanding the impact of environmental factors on health, making this approach both relevant and promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study. 2. Ability to provide informed consent. 3. Able to read and speak English 4. Male or female, aged \>=18 5. Able to travel to the NIEHS CRU for study visits or travel to an offsite event or conference. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Not willing to have samples stored for future use. 2. Current pregnancy or lactation, by participant verbal confirmation. 3. Any condition that, in the investigator's opinion, places the participant at undue risk for complications associated with required study procedures. Participants will be enrolled according to pre-defined host (e.g. disease, genetic, or demographic) or environmental (exposure) characteristics.
Where it's running
-
NIEHS Clinical Research Unit (CRU)
Research Triangle Park, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Lawrence S Kirschner, M.D. — National Institute of Environmental Health Sciences (NIEHS)
- Study coordinator: NIEHS Join A Study Recruitment Group
- Email: myniehs@nih.gov
- Phone: (855) 696-4347
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.