Understanding how ACAD10 and ACAD11 affect fat metabolism and diabetes
Official title: Defining the roles of ACAD10/11 in hydroxy lipid catabolism and metabolic disease
Funded at Washington University · NIH-11330373 · Data updated 2026-11-12
Aimed at uncovering how two enzymes, ACAD10 and ACAD11, help break down fats in the body and how this relates to adult-onset diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $400,244 |
| NIH project number | 5R01DK137976-03 |
| Project ID | NIH-11330373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for type 2 diabetes or metabolic disease who may have altered fatty acid metabolism.
✕Less likely to help
Individuals without metabolic disease or with unrelated conditions may see no direct benefit.
What this research studies
This project examines how fatty acid breakdown works in people with adult-onset diabetes and how unusual fat molecules are processed in the liver. Researchers will study ACAD10 and ACAD11 enzymes to see how they convert certain 4-hydroxy fatty acids into usable energy. The work uses human-relevant models and advanced mass spectrometry to map these pathways and their influence on insulin resistance and metabolic health. The goal is to identify potential targets that could improve fat metabolism and reduce diabetes-related complications.
Why it matters
Potential benefit: If successful, the work could highlight new ways to improve fat metabolism and metabolic health in adults with diabetes.
How similar studies have gone: Earlier studies show that unusual fatty acids and ACAD enzymes can influence metabolism, but ACAD10/ACAD11 roles are not fully understood and findings are exploratory.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Pagliarini, David J — Washington University
- Study coordinator: Pagliarini, David J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.