How metabolic diseases affect circadian rhythms and dietary therapy
Mechanisms of Circadian Rhythm Modulation by Metabolic Disease and Dietary Therapy
This study is looking at how our body’s internal clock affects metabolic diseases, especially in people with Alzheimer's and Parkinson's, to see if fixing sleep patterns and diet can help improve their symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10993167 on NIH RePORTER |
What this research studies
This research investigates the relationship between metabolic diseases and circadian rhythms, particularly in the context of neurological disorders like Alzheimer's and Parkinson's. By using Drosophila as a model organism, the study aims to explore how disruptions in circadian rhythms can worsen symptoms of these diseases, such as sleep disturbances and metabolic issues. The research will analyze the molecular mechanisms linking metabolism and circadian function, potentially leading to dietary interventions that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other neurological disorders that exhibit circadian rhythm disruptions.
Not a fit: Patients without neurological disorders or those not experiencing circadian rhythm disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary therapies that improve sleep and overall quality of life for patients with neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the links between metabolism and circadian rhythms, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Palladino, Michael John — University of Pittsburgh at Pittsburgh
- Study coordinator: Palladino, Michael John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.